Analysis of the dynamics and origin of epileptic activity in patients with tuberous sclerosis evaluated for surgery of epilepsy

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Alberto J R LealEulália Calado

Abstract

The epilepsies associated with the tuberous sclerosis complex (TSC) are very often refractory to medical therapy. Surgery for epilepsy is an effective alternative when the critical link between the localization of seizure onset in the scalp and a particular cortical tuber can be established. In this study we perform analysis of ictal and interictal EEG to improve such link. The ictal and interictal recordings of four patients with TSC undergoing surgery for epilepsy were submitted to independent component analysis (ICA), followed by source analysis, using the sLORETA algorithm. The localizations obtained for the ictal EEG and for the average interictal spikes were compared. The ICA of ictal EEG produced consistent results in different events, and there was good agreement with the tubers that were successfully removed in three of the four patients (one patient refused surgery). In some patients there was a large discrepancy between the localization of ictal and interictal sources. The interictal activity produced more widespread source localizations. The use of ICA of ictal EEG followed by the use of source analysis methods in four cases of epilepsy and TSC was able to localize the epileptic generators very near the lesions succ...Continue Reading

References

Jan 1, 1991·Electroencephalography and Clinical Neurophysiology·J C De MunckH Spekreijse
Nov 1, 1966·Archives of Neurology·P PerotT Rasmussen
Nov 1, 1995·Neural Computation·A J Bell, T J Sejnowski
Jul 1, 1993·Epilepsia·E M BebinM R Gomez
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·S MakeigT J Sejnowski
Mar 29, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G LantzI Rosén
Aug 27, 2004·Epilepsia·Elena UrrestarazuJulio Artieda
Sep 24, 2004·Brain Topography·Michael WagnerJörn Kastner
Jun 2, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Alberto J R LealJosé P Vieira
Mar 28, 2007·Epilepsia·Gregory L HolmesUNKNOWN Tuberous Sclerosis Study Group
May 9, 2007·Epilepsia·Floor E JansenOnno van Nieuwenhuizen

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Citations

Mar 13, 2009·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Yaki SternEsther Adi-Japha
Aug 5, 2011·Journal of Cognitive Neuroscience·David J WhiteRichard B Silberstein
Feb 16, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Astrid van der HeideFloor E Jansen
Apr 12, 2014·Frontiers in Human Neuroscience·Alexander HunoldChristos Papadelis

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