Analysis of the effect of cannabinoids on GABAergic neurotransmission in the substantia nigra pars reticulata.

Naunyn-Schmiedeberg's Archives of Pharmacology
Ilka Wallmichrath, Bela Szabo

Abstract

The CB(1) cannabinoid receptor is widely distributed in the central nervous system. The substantia nigra pars reticulata (SNR) belongs to the brain regions with the highest density of CB(1) receptors. According to anatomical studies, most of the CB(1) receptors in the SNR are localized on terminals of striatonigral GABAergic neurons. The aim of the present study was to clarify the function of these receptors.Electrophysiological properties of SNR neurons were studied in brain slices with the patch-clamp technique. Inhibitory postsynaptic currents (IPSCs) were elicited in parasagittal slices by electrical stimulation in the internal capsule. The mixed CB(1)/CB(2) cannabinoid receptor agonist WIN55212-2 (1 microM and 10 microM) concentration dependently decreased the amplitude of IPSCs. CP55940, another mixed CB(1)/CB(2) cannabinoid receptor agonist, also lowered IPSC amplitude. Superfused alone, the CB(1)-selective antagonist SR141716A (1 microM) increased the amplitude of IPSCs. In interaction experiments, SR141716A (1 microM) prevented the inhibition produced by WIN55212-2 (1 microM). WIN55212-2 (1 microM) had no effect on GABAergic currents elicited by ejection of muscimol (1 mM) to the surface of the slices. WIN55212-2 (10 m...Continue Reading

Citations

Jan 29, 2003·Current Opinion in Pharmacology·Jonathan M Brotchie
Jul 15, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T M Fong, S B Heymsfield
Dec 4, 2003·The Journal of Comparative Neurology·Marisela MoralesDiana Hyun-Jin Jho
Mar 14, 2008·European Journal of Pharmacology·Richard Z ChenTung M Fong
May 15, 2007·Progress in Brain Research·Ulrich MisgeldYevgenij Yanovsky
Jun 9, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Silvia MarinelliNicola B Mercuri
May 17, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mario van der SteltJonathan M Brotchie
Jul 5, 2003·Physiological Reviews·Tamas F FreundDaniele Piomelli

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