PMID: 11337013May 5, 2001Paper

Analysis of the effects of growth hormone, exercise and food restriction on cancellous bone in different bone sites in middle-aged female rats

Mechanisms of Ageing and Development
Jameela BanuD N Kalu

Abstract

The aim of this study is to determine the effects of growth hormone (GH), exercise (EX), GH+EX and food restriction on cancellous bone in middle-aged female rats. Female F344 rats aged 13 months were divided into (1) age-matched controls; (2) GH treated (2.5 mg/kg. 5 day/week); (3) EX (voluntary wheel running); (4) GH+EX; and (5) food restricted (FR) (fed 60% of the ad libitum food intake). The animals were treated for 18 weeks, at the end of which they were sacrificed. Cancellous bone and cortical bone in the fourth lumbar vertebra, proximal tibial metaphysis (PTM), distal femoral metaphysis (DFM) and femoral neck (NF) were analyzed using peripheral quantitative computerized tomography (pQCT) densitometry. Growth hormone increased cancellous bone area, cancellous bone mineral content, cortical bone area and cortical bone mineral content in the vertebra, PTM, DFM and NF. The tibial muscle wet weight was increased significantly after GH treatment. Exercise increased the cancellous bone area in the vertebra, PTM and DFM. Cortical bone area and cortical bone mineral content increased after EX in the vertebra, PTM, DFM and NF. No significant change was seen in the tibial muscle wet weight after EX. Growth hormone+EX increased cance...Continue Reading

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Citations

Sep 2, 2008·Journal of Bone and Mineral Metabolism·Jameela BanuGabriel Fernandes
Apr 16, 2010·Journal of Bone and Mineral Metabolism·Jameela BanuGabriel Fernandes
Feb 7, 2008·Immunologic Research·Gabriel Fernandes
Nov 21, 2000·Free Radical Biology & Medicine·J J RamseyR Weindruch
Mar 25, 2006·Lipids in Health and Disease·Jameela BanuGabriel Fernandes
Feb 18, 2016·Annals of the New York Academy of Sciences·Tsang-hai Huang, Gene P Ables
Jan 20, 2006·American Journal of Physical Anthropology·Marina L SardiHéctor M Pucciarelli
Jun 26, 2009·American Journal of Physical Anthropology·Karen L BaabTimothy Hanson
Mar 27, 2015·International Journal of Endocrinology·Janina KueperJosh E Schroeder
Dec 19, 2012·Nutrition Research·Jameela BanuGabriel Fernandes
Aug 11, 2007·Journal of Applied Physiology·Nancy M DimarcoCharlotte Barney Sanborn
May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·Elizabeth C BrownCharles K Lumpkin
Feb 14, 2020·Journal of Anatomy·Miriam Corina VeraGustavo Roberto Cointry
Feb 21, 2019·Acta Cirúrgica Brasileira·Iara Inácio BotegaJosé Batista Volpon

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