Analysis of the effluxes of sodium, potassium and chloride ions from smooth muscle in normal and hypertonic solutions

The Journal of Physiology
A F Brading

Abstract

1. Efflux curves of (24)Na, (42)K and (36)Cl from the guinea-pig taenia coli were obtained in normal Krebs solution, and in hypertonic Krebs solution in which the osmolarity had been doubled by the addition of sucrose.2. The efflux curves were complex, and in order to get average curves each was analysed as the sum of three exponential terms, and average curves were constructed from the means of the constants found.3. In order to estimate the membrane permeability to the ions, it was necessary to make assumptions as to the distribution of ions in the tissue. Several models have been examined and the predictions of the models with respect to the membrane properties were compared with the data obtained by using electrophysiological methods by other workers.4. It was found that reasonable predictions of membrane properties could only be made using models in which the majority of the rapidly exchanging sodium is considered to be extracellular. This amount of sodium is more than can be accounted for as freely dissolved in the extracellular water.5. A possible interpretation of the ion exchange and distribution would be to suppose that some proportion of the three ions is contained in an extracellular compartment not available to the...Continue Reading

Citations

Mar 1, 1986·Irish Journal of Medical Science·C T Kirkpatrick, C G Bullock
Jan 1, 1975·Progress in Biophysics and Molecular Biology·T Tomita
Nov 1, 1979·International Journal of Bio-medical Computing·G A SmithJ A Madden
Jul 1, 1982·International Journal of Bio-medical Computing·G A SmithJ G Llaurado
Oct 1, 1986·Journal of Cellular Physiology·M KinoA Aviv
Jun 5, 2001·Japanese Journal of Pharmacology·K Kitamura, J Yamazaki
Jul 1, 1980·Pflügers Archiv : European journal of physiology·J H Widdicombe, A F Brading
Dec 1, 1980·Pflügers Archiv : European journal of physiology·J D Schiff, N I Overweg
Oct 1, 1978·FEBS Letters·H P MeissnerM Preissler
Nov 1, 1983·The American Journal of Physiology·H C Parkington

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.