Analysis of the expression of outer-membrane proteins in Neisseria meningitidis in iron-replete and iron-deficient media

FEMS Microbiology Letters
C M FerreirósM Pintor

Abstract

A total of 103 Neisseria strains, including 42 carrier and 40 invasive N. meningitidis and 21 commensal species were studied. Outer-membrane proteins from carrier and invasive N. meningitidis showed similar molecular mass distributions (except in the range from 78 to 82 kDa in which 90% of the invasive but only 47.6% of the carrier strains expressed proteins), many strains showing neither class II (41 kDa) nor class III (38 kDa) proteins. When grown in iron-restricted conditions proteins were induced mainly in the ranges from 62 to 92 kDa with no significant differences between groups. Commensal species, both in normal and in iron-restricted conditions, showed outer-membrane protein patterns different from those of N. meningitidis in several molecular mass ranges. Cluster analysis based on expression of principal outer-membrane proteins allowed the differentiation of commensal species and N. meningitidis, although not that of the invasive and carrier groups within the latter.

Citations

Mar 1, 1995·Research in Microbiology·T Gallot-LavalléeG Dubray
Feb 1, 1993·Infection and Immunity·D A Ala'AldeenS P Borriello
Jan 1, 1993·Research in Microbiology·M T CriadoC M Ferreirós

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