PMID: 16538017Mar 16, 2006Paper

Analysis of the factors associated with Tc-99m pertechnetate uptake in thyrotoxicosis and graves' disease

Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi
Yo Kidokoro-KuniiShinichi Oikawa

Abstract

To determine the factors associated with 20 minute Tc-99m pertechnetate thyroid uptake, we examined all patients in whom thyrotoxicosis was diagnosed at Chiba-Hokusoh Hospital, Nippon Medical School from 2001 April through 2003 March. Patients with thyrotoxicosis diagnosed during this period were 57 with Graves' disease (76%), 11 with transient hyperthyroxinemia (TH)(14.7%), and 7 with subacute thyroiditis (SAT)(9.3%). The uptake of Tc-99m ranged from 0.97% to 40.1% in Graves' disease and from 0.15% to 0.8% in TH. Although TH may include spontaneous resolution of Graves' disease as well as painless thyroiditis, no treatment was necessary for these patients. Uptake in all patients with SAT was less than 0.5%. There were significant correlations between the level of Tc-99m uptake and the levels of free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH)-binding inhibitory immunoglobulin (TBII), and thyroid stimulating antibody (TSAb) in patients with Graves' disease. Older patients with Graves' disease showed lower uptake than did younger patients. Both Tc-99m pertechnetate uptake and TBII levels, but not fT3, fT4 or TSAb levels, at the beginning of antithyroid drug treatment correlated significantly w...Continue Reading

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Citations

Dec 1, 2012·Nuclear Medicine and Molecular Imaging·Teik Hin TanZanariah Hussein
Feb 26, 2015·Nuclear Medicine Communications·Daša ŠfiligojKatja Zaletel
Dec 17, 2014·Chemical Communications : Chem Comm·Casey J MassenaOrion B Berryman
Sep 27, 2014·Thyroid : Official Journal of the American Thyroid Association·Charumathi BaskaranLynne L Levitsky
Apr 25, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Manouchehr NakhjavaniMehrshad Abbasi
Jan 27, 2021·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Simone A SchenkeMichael C Kreissl

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