Analysis of the foveal microvasculature in sickle cell disease using swept-source optical coherence tomography angiography.

Scientific Reports
A MokraneAudrey Giocanti-Aurégan

Abstract

Ischemic microangiopathy was clearly identified in sickle cell disease (SCD) using fluorescein angiography. A prospective observational clinical study was conducted to assess the foveal avascular zone (FAZ) area and explore perifoveal microvasculature changes in the superficial (SCP) and deep (DCP) capillary plexus using optical coherence tomography angiography (OCTA) and compare two genotypes-HbS/HbS (HbSS) and HbS/HbC (HbSC)-to control. All consecutive patients with electrophoretic confirmation of SCD were included. Swept-source OCTA scans (Triton Plus, Topcon, Tokyo, Japan) with a 3 × 3-mm scanning area and ultra-wide field (UWF) retinography (California, Optos, Fife, Scotland) were recorded for all patients. For OCTA analysis, preset parameters were used to segment the SCP and DCP. The FAZ area was manually assessed. The number of vascular branching points was automatically assessed based on the vascular skeletonization using ImageJ software. Eyes were staged based on Goldberg's classification of SCD retinopathy (SCDR) using UWF imaging. Forty-six eyes of 24 patients were included in the HbSS (n = 27) and HbSC (n = 19) groups and 16 eyes of 8 unaffected patients in a control group. In the DCP, the FAZ was significantly larg...Continue Reading

References

Jun 1, 1976·The British Journal of Ophthalmology·G K AsdourianM F Goldberg
Jun 1, 1991·Archives of Ophthalmology·R J SandersL Magargal
Mar 1, 1990·The British Journal of Ophthalmology·P D FoxG R Serjeant
Jul 1, 1987·The British Journal of Ophthalmology·C M LeeM F Goldberg
Dec 1, 1974·Archives of Ophthalmology·T S StevensM F Goldberg
May 1, 1973·American Journal of Ophthalmology·I Acacio, M F Goldberg
Apr 1, 1974·American Journal of Ophthalmology·S J Ryan
Mar 1, 1971·American Journal of Ophthalmology·M F Goldberg
Oct 12, 2004·Lancet·Marie J Stuart, Ronald L Nagel
Mar 17, 2010·Microscopy Research and Technique·Ignacio Arganda-CarrerasCarlos Ortiz-De-Solorzano
Aug 2, 2011·Investigative Ophthalmology & Visual Science·Sarah TickMichel Paques
Apr 5, 2012·Journal français d'ophtalmologie·N LevezielE Souied
Oct 28, 2015·Retinal Cases & Brief Reports·Christian J SanfilippoIrena Tsui
Dec 30, 2015·Glia·Audrey Giocanti-AureganRamin Tadayoni
Jan 10, 2016·American Journal of Ophthalmology·Wilfried MinvielleEric H Souied
Dec 23, 2016·Retina·Khalil Ghasemi FalavarjaniIrena Tsui
Feb 6, 2017·Lancet·Russell E WareMiguel R Abboud
May 11, 2017·PloS One·Marion R MunkMartin S Zinkernagel
Jul 25, 2019·The British Journal of Ophthalmology·Giselle LynchToco Y Chui

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

ImageJ
MatLab Image Processing Toolbox
Plugins
PRISM
Analyze Skeleton
Matlab
OCT
SPSS
XLSTAT
OCTA

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.