Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor

Molecular Endocrinology
M JeyakumarM K Bagchi

Abstract

The nuclear hormone receptors belonging to the steroid/thyroid/retinoid receptor superfamily are ligand-inducible transcription factors. These receptors modulate transcription of specific cellular genes, either positively or negatively, by interacting with specific hormone response elements located near the target promoters. Recent studies indicated that the hormone- occupied, DNA-bound receptor acts in concert with a cellular coregulatory factor, termed coactivator, and the basal transcription machinery to mediate gene activation. Consistent with this scenario, a number of nuclear proteins with potential coactivator function have been isolated. In the present study, we demonstrate that steroid receptor coactivator-1 (SRC-1), a recently isolated candidate coactivator, functions as a positive regulator of the thyroid hormone receptor (TR)-mediated transactivation pathway. In transient transfection experiments, coexpression of SRC-1 significantly enhanced ligand-dependent transactivation of a thyroid hormone response element (TRE)-linked promoter by human TRbeta. Our studies revealed that deletion of six amino acids (451-456) in the extreme COOH-terminal region of TRbeta resulted in a receptor that retained the ability to bind T3...Continue Reading

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Citations

Nov 10, 2013·Journal of Molecular Endocrinology·Christopher J MillardJohn W R Schwabe
Jun 9, 2000·Annual Review of Physiology·J Zhang, M A Lazar
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·F LabrieR Veilleux
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May 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yaluan MaJoachim Fandrey
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May 27, 2020·PLoS Genetics·Stine M PræstholmLars Grøntved
Jan 31, 2009·Endocrinology·Maria Izabel Chiamolera, Fredric E Wondisford
Jun 28, 2001·Physiological Reviews·P M Yen
Jun 15, 2017·Molecular & Cellular Proteomics : MCP·Joanna K LempiäinenJorma J Palvimo

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