Analysis of the genome of the sexually transmitted insect virus Helicoverpa zea nudivirus 2.

Viruses
John P BurandDaniel L Rock

Abstract

The sexually transmitted insect virus Helicoverpa zea nudivirus 2 (HzNV-2) was determined to have a circular double-stranded DNA genome of 231,621 bp coding for an estimated 113 open reading frames (ORFs). HzNV-2 is most closely related to the nudiviruses, a sister group of the insect baculoviruses. Several putative ORFs that share homology with the baculovirus core genes were identified in the viral genome. However, HzNV-2 lacks several key genetic features of baculoviruses including the late transcriptional regulation factor, LEF-1 and the palindromic hrs, which serve as origins of replication. The HzNV-2 genome was found to code for three ORFs that had significant sequence homology to cellular genes which are not generally found in viral genomes. These included a presumed juvenile hormone esterase gene, a gene coding for a putative zinc-dependent matrix metalloprotease, and a major facilitator superfamily protein gene; all of which are believed to play a role in the cellular proliferation and the tissue hypertrophy observed in the malformation of reproductive organs observed in HzNV-2 infected corn earworm moths, Helicoverpa zea.

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Citations

Mar 10, 2018·Viruses·William H PalmerRonald P van Rij
Feb 28, 2014·Journal of Virology·Ruo-Lin ChengChuan-Xi Zhang
May 24, 2017·Parasitology·Jérémy GauthierElisabeth A Herniou
Jul 28, 2018·Molecular Biology and Evolution·Gaelen R BurkeScott M Geib
Sep 19, 2014·PLoS Genetics·Gaelen R BurkeMichael R Strand
Nov 3, 2014·Annual Review of Virology·Michael R Strand, Gaelen R Burke
Apr 14, 2020·Genome Biology and Evolution·Ruo-Lin ChengChuan-Xi Zhang
Mar 13, 2017·The Journal of General Virology·Annie BézierElisabeth A Herniou
Jun 8, 2013·Molecular Ecology·Stineke van HouteMonique M van Oers
Jan 9, 2015·Virology·Loy E Volkman
Mar 15, 2014·The Journal of Experimental Biology·Shelley A AdamoDon Stoltz

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Datasets Mentioned

BETA
JN418988

Software Mentioned

EMBOSS Water
CD
SMART
MUSCLE
BLAST
CAP3
ClustalX
Glimmer
TMHMM
PHRED

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