Analysis of the global regulator Lae1 uncovers a connection between Lae1 and the histone acetyltransferase HAT1 in Fusarium fujikuroi

Applied Microbiology and Biotechnology
Eva-Maria NiehausBettina Tudzynski

Abstract

The fungus Fusarium fujikuroi causes "bakanae" disease of rice due to its ability to produce gibberellins (GAs), a family of plant hormones. Recent genome sequencing revealed the genetic capacity for the biosynthesis of 46 additional secondary metabolites besides the industrially produced GAs. Among them are the pigments bikaverin and fusarubins, as well as mycotoxins, such as fumonisins, fusarin C, beauvericin, and fusaric acid. However, half of the potential secondary metabolite gene clusters are silent. In recent years, it has been shown that the fungal specific velvet complex is involved in global regulation of secondary metabolism in several filamentous fungi. We have previously shown that deletion of the three components of the F. fujikuroi velvet complex, vel1, vel2, and lae1, almost totally abolished biosynthesis of GAs, fumonisins and fusarin C. Here, we present a deeper insight into the genome-wide regulatory impact of Lae1 on secondary metabolism. Over-expression of lae1 resulted in de-repression of GA biosynthetic genes under otherwise repressing high nitrogen conditions demonstrating that the nitrogen repression is overcome. In addition, over-expression of one of five tested histone acetyltransferase genes, HAT1, w...Continue Reading

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Citations

Dec 6, 2017·Applied Microbiology and Biotechnology·Slavica Janevska, Bettina Tudzynski
Dec 12, 2018·Nature Reviews. Microbiology·Nancy P Keller
Mar 21, 2019·Annual Review of Phytopathology·Yun ChenZhonghua Ma
Jul 22, 2020·Molecular Microbiology·Kristina ShostakRajagopal Subramaniam
Sep 1, 2021·Fungal Genetics and Biology : FG & B·Edoardo PiomboDavide Spadaro

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Methods Mentioned

BETA
PCR
phosphotransferase
fluorescence microscopy
RNA-seq
immunoprecipitation
acetylation
ChIP-seq

Software Mentioned

Clustal Omega
AxioVison Rel
Functional Catalog ( FunCat )

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