PMID: 8970969Dec 1, 1996Paper

Analysis of the human env-specific cytotoxic T-lymphocyte (CTL) response in natural human immunodeficiency virus type 1 infection: low prevalence of broadly cross-reactive env-specific CTL

Journal of Virology
A J CarmichaelP Sissons

Abstract

Major histocompatibility complex-restricted cytotoxic T lymphocytes (CTL) are part of the cellular immune response to persistent virus infections. Candidate vaccines against human immunodeficiency virus type 1 (HIV-1) should elicit broad cross-reactive immunity to confer protection against different strains of HIV-1. As it is likely that candidate vaccines will include the envelope gene product Env, we determined the proportion of CTL clones which recognized variable and conserved determinants in three env variants during natural infection. Limiting dilution analysis was used to characterize numerous short-term CTL clones derived from peripheral blood of HIV-1-infected subjects, using split-well analysis to assay cytotoxicity against target cells expressing gp160env of HIV-1 strains IIIB, MN, and RF. In 9 of 12 HIV-1-infected subjects, at the clonal level most env-specific CTL recognized determinant(s) within one env variant but not in the other variants. In some subjects, CTL recognized multiple nonconserved determinants in different variants. The pattern of recognition of different env variants was relatively stable over time. In most of the patients studied, the proportion of CTL which showed cross-recognition of conserved d...Continue Reading

References

May 25, 1990·Journal of Immunological Methods·N J AlpL K Borysiewicz
Jul 23, 1987·Nature·B D WalkerR T Schooley
Jul 7, 1983·The New England Journal of Medicine·A J McMichaelP A Beare
Mar 12, 1982·Journal of Immunological Methods· Fazekas de St Groth
Sep 1, 1994·The Journal of Experimental Medicine·R A Koup
Jul 13, 1995·Nature·J P Moore

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Citations

May 19, 1998·Nature Medicine·C A Heilman, D Baltimore
Oct 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lyle R McKinnonFrancis A Plummer
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohammed L GarbaJeffrey A Frelinger

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