PMID: 1197141Nov 1, 1975Paper

Analysis of the hypotensive action of prazosin

Postgraduate Medicine
J W ConstantineH J Hess

Abstract

Results of animal studies indicate that the hypotensive effect of prazosin is due to vasodilatation which is dependent on two discernible components of drug action: (1) direct relaxation of vascular smooth muscle and (2) interference with peripheral sympathetic function at a site distal to the alpha-adrenergic receptor.

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