Analysis of the immune response in sheep efferent lymph during Salmonella abortusovis infection

Veterinary Immunology and Immunopathology
I GohinF Lantier

Abstract

The efferent lymph duct of the ovine prescapular lymph node was cannulated, and Salmonella abortusovis (SAO), a specific pathogen for sheep inducing abortion and mortality of newborn lambs, was inoculated by the subcutaneous route in this lymph node drained area. While the prescapular lymph node draining the inoculation site represented an efficient barrier for the vaccinal SAO Rv6 strain spreading, SAO 15/5 virulent bacteria were steadily detected in efferent lymph of infected sheep. The inoculation of the virulent strain of SAO induced a greater increase of the cell output than did the attenuated vaccinal strain, but proportions of blast cells appearing in the efferent lymph were similar in both cases. Flow cytometry analysis showed that B and T cell outputs were both increased during SAO infections, but while T cell subset proportions slightly decreased, B cell percentages significantly rose, and, at the peak response, almost all of the lymphoblast cells were activated B cells. Typical antibody profiles characteristic of a primary immune response were observed, and antibody titres were greater in the efferent lymph of animals inoculated with the virulent strain of SAO. Many of the cytokine mRNAs we investigated were steadily...Continue Reading

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Citations

Jun 1, 2001·Journal of Immunological Methods·A MontagneA C Lalmanach
Dec 28, 1999·Microbes and Infection·A C Lalmanach, F Lantier
May 8, 1999·Immunology·D M HaigH R Miller
Mar 13, 2001·The Veterinary Journal·P MastroeniG Dougan
Jan 10, 2017·Frontiers in Immunology·Morgan C HunterCornelia Halin
Jul 14, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Sophie Wirz-DittusAndreas S Waldvogel
Nov 16, 2018·The Journal of Experimental Medicine·Guilhem R ThierryMarc Bajénoff
Jan 17, 2015·Expert Review of Vaccines·Thilini An MahakapugeJean-Pierre Y Scheerlinck
May 1, 2021·International Journal of Molecular Sciences·Louise A Johnson

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