Analysis of the immune responses in chimpanzees infected with HIV type 1 isolates.

AIDS Research and Human Retroviruses
Laure Y JuompanF J Novembre

Abstract

The mechanisms of resistance to AIDS development in HIV-1-infected chimpanzees have remained elusive. Unique among chimpanzees naturally or experimentally infected with HIV, several animals of the Yerkes cohort have progressed to clinical AIDS with selection of isolates showing increased pathogenicity for chimpanzees. We compared progressors vs. nonprogressors among the HIV-infected chimpanzees that made up this cohort, eight of which have been infected with HIV-1 for over 14 years. The additional two progressors were infected de novo with chimpanzee-pathogenic HIV, rapidly leading to a progressor status. Nonprogressors were characterized by normal CD4(+) T cell counts and the absence of detectable viremia. In contrast, progressor chimpanzees had relatively high plasma viral loads associated with a dramatic loss of CD4(+) T cells. The analysis of immune responses showed a similar amplitude and breadth of ELISPOT T cell responses in both groups. HIV-specific proliferative responses were, however, absent in the progressor animals, which also exhibited increased levels of immune activation characterized by elevated levels of the circulating chemokines IP-10 and MCP-1. Of interest was the conservation of potent NK cell activity in ...Continue Reading

References

Apr 1, 1989·The Journal of Clinical Investigation·J F KrowkaJ M Homsy
Dec 1, 1984·Lancet·D P FrancisA K Harrison
Jan 1, 1995·Nature Medicine·S Rowland-JonesT Corrah
Mar 1, 1993·Immunology Today·M Clerici, G M Shearer
Jul 1, 1993·AIDS Research and Human Retroviruses·G FerrariK J Weinhold
May 1, 1997·Journal of Virology·F J NovembreH M McClure
Aug 15, 1997·The Journal of Clinical Investigation·C E MackewiczJ A Levy
May 30, 1998·Clinical and Diagnostic Laboratory Immunology·J FanJ L Fahey
Dec 22, 1998·The Journal of Experimental Medicine·S A Kalams, B D Walker
Sep 29, 1999·Immunology Today·H Soudeyns, G Pantaleo
Sep 9, 2000·The Journal of Infectious Diseases·S P O'NeilH M McClure
Sep 6, 2002·The New England Journal of Medicine·Stephanie JostLuc Perrin
Nov 5, 2002·Journal of Virology·Gabrielle T BelzPeter C Doherty
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Todd M Allen, Marcus Altfeld
May 27, 2006·Science·Brandon F KeeleBeatrice H Hahn
Sep 28, 2006·Blood·Ivona PandreaGuido Silvestri

❮ Previous
Next ❯

Citations

Sep 5, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Paula C SotoAjit Varki
Nov 5, 2008·Expert Review of Vaccines·Silvia BaroncelliAndrea Cara
Jul 30, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Thalía Garcia-TellezMichaela Müller-Trutwin
Aug 19, 2016·The Journal of General Virology·Babs E VerstrepenGerrit Koopman
Aug 16, 2019·Journal of Neurovirology·R BurlacuC L Achim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.