Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage

Memórias do Instituto Oswaldo Cruz
Felipe Gomes NavecaRajendranath Ramasawmy

Abstract

Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis. To define the immunologic biomarkers that correlate with acute ZIKV infection. We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining. ZIKV-infected patients present a striking systemic inflammatory response with high levels of pro-inflammatory mediators. Despite the strong inflammatory pattern, IL-1Ra and IL-4 are also induced during the acute infection. Interestingly, the inflammatory cytokines IL-1β, IL-13, IL-17, TNF-α, and IFN-γ; chemokines CXCL8, CCL2, CCL5; and the growth factor G-CSF, displayed a bimodal distribution accompanying viremia. While this is the first manuscript to document bimodal distributions of viremia in ZIKV infection, this has been documented in other viral infections, with a primary viremia peak during mild systemic disease and a secondary peak associated with distrib...Continue Reading

References

Sep 2, 2003·Journal of Leukocyte Biology·Jesper MelchjorsenSøren R Paludan
Jul 9, 2004·Veterinary Research·Philip Scott Mellor, Christopher Hamblin
Oct 23, 2004·The Journal of Infectious Diseases·Jan ter MeulenAndreas Kaufmann
Aug 17, 2005·Journal of Virology·Robyn S KleinMichael S Diamond
Jun 8, 2007·Emerging Infectious Diseases·Robert S LanciottiGrant L Campbell
Aug 25, 2007·Annals of Tropical Paediatrics·Patcharapa SathupanYong Poovorawan
Oct 19, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Francesca GotschSonia S Hassan
Apr 9, 2008·Emerging Infectious Diseases·Regina Maria Pinto de FigueiredoIzeni Pires Farias
Aug 6, 2008·Emerging Infectious Diseases·Robert S LanciottiMark R Duffy
Jan 27, 2009·Virology Journal·K R GurukumarD Cecilia
Aug 2, 2011·Cytokine & Growth Factor Reviews·Mingli LiuJonathan K Stiles
May 29, 2012·Immunity·Albert Zlotnik, Osamu Yoshie
Sep 27, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sabra L Klein
Mar 1, 2013·Muscle & Nerve·Sharon Chiang, Eroboghene E Ubogu
Mar 15, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·E OehlerF Ghawche
Jul 16, 2014·BMC Infectious Diseases·Ana Carolina Campi-AzevedoOlindo Assis Martins-Filho
Jun 19, 2015·Journal of Virology·Rodolphe HamelDorothée Missé
Dec 26, 2015·Medical Microbiology and Immunology·Dennis TappeJonas Schmidt-Chanasit
Mar 11, 2016·MMWR. Morbidity and Mortality Weekly Report·Wanderson Kleber de OliveiraGiovanny Vinícius Araújo de França
Dec 16, 2016·Annals of Neurology·Alice M M OrnelasRenato S Aguiar
Jan 6, 2017·Open Forum Infectious Diseases·Rafael Mello GalliezFernanda Tovar Moll
May 5, 2017·Journal of Virology·Vidyanath ChaudharyDong-Yan Jin
Jun 8, 2017·Memórias do Instituto Oswaldo Cruz·Felipe Gomes NavecaPedro Fernando da Costa Vasconcelos
Oct 11, 2017·The Journal of Allergy and Clinical Immunology·Michael R EdwardsSebastian L Johnston

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Citations

Feb 21, 2019·The Journal of Infectious Diseases·Fabio Seiti Yamada YoshikawaMaria Notomi Sato
Apr 19, 2020·Current Opinion in Neurology·Shenjian Ai, Robyn S Klein
Jul 30, 2020·Journal of Leukocyte Biology·Tertuliano Alves Pereira NetoHelton da Costa Santiago
Oct 26, 2018·PLoS Neglected Tropical Diseases·Mehdi R M BidokhtiSiddappa N Byrareddy
Sep 26, 2020·Frontiers in Immunology·Loulieta NazeraiAllan Randrup Thomsen
Dec 13, 2019·Journal of Immunology Research·Ocilma B de QuentalLuiz C de Abreu
Nov 26, 2020·Pathogens and Disease·Thekra KhushafaZhu Haixia
Jun 3, 2021·Cells·Iury Amancio PaivaLuzia Maria de-Oliveira-Pinto
Jun 2, 2020·Virus Research·Joel Henrique EllwangerJosé Artur Bogo Chies
Aug 20, 2021·The Journal of General Virology·Joseph A WestrichCandace K Mathiason

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
ELISA

Software Mentioned

JMP
GraphPad Prism
WEKA
GraphPad
MedCalc
R
Cytoscape

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