PMID: 8605902Oct 1, 1995Paper

Analysis of the immunological humoral response to Mycobacterium tuberculosis glycolipid antigens (DAT, PGLTb1) for diagnosis of tuberculosis in HIV-seropositive and -seronegative patients

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
N SimonneyP H Lagrange

Abstract

Using an enzyme immunoassay (EIA) test, the concentrations of IgG antibodies against 2,3 diacyl trehalose (DAT) and phenolic glycolipid Tb1 (PGLTb1) were measured in the sera of 153 patients with active tuberculosis, 50 of whom were coinfected with HIV, and in the sera of 152 healthy blood donors, 149 asymptomatic HIV-seropositive patients, 12 HIV-seronegative patients with conditions simulating tuberculosis, 23 HIV-seropositive patients with disseminated infection caused by mycobacteria other than tuberculosis and 24 HIV-seropositive patients with pulmonary disease from whom mycobacteria was not isolated in culture. A slightly lower percentage (74%) of the HIV-seropositive than the HIV-seronegative (77%) tuberculosis patients were positive for anti-DAT and anti-PGLTb1 IgG antibodies, with a specificity ranging from 91 to 95%. There was no significant difference between EIA sensitivity in smear-positive and smear-negative patients with pulmonary tuberculosis for all HIV immune statuses and sites of disease (pulmonary vs. extrapulmonary). In HIV-seropositive patients, however, sensitivity was always lower for disseminated tuberculosis than for localized tuberculosis. Combining data for both the smear test and the EIA maximized s...Continue Reading

References

Jul 31, 1975·The New England Journal of Medicine·B J McNeilS J Adelstein
Aug 1, 1992·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·L BarreraJ Castagnino
Apr 1, 1992·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M RidellM Magnusson
Aug 1, 1991·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·H C BerlieH L David
Dec 1, 1990·Journal of Clinical Microbiology·E SadaM Torres
Oct 1, 1989·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·P CruaudH L David
Aug 17, 1987·European Journal of Biochemistry·M DafféG Lanéelle
Nov 1, 1987·The Journal of Infectious Diseases·W R LevisP Fried
May 26, 1966·The New England Journal of Medicine·T J Vecchio
Jun 1, 1995·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·G Daleine, P H Lagrange
Jan 18, 1995·JAMA : the Journal of the American Medical Association·M C RaviglioneA Kochi
May 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J P Van VoorenA Drowart
Sep 1, 1993·The Journal of Infectious Diseases·J J EllnerW R Jacobs
Feb 1, 1993·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·C SavageH Leclerc

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Citations

Jul 14, 2005·Journal of Immunoassay & Immunochemistry·Friederike TraunmüllerHaider Abdulla Abdel Salam
Nov 19, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Gunther K SchleicherJan A Verschoor
Jun 11, 2014·Critical Reviews in Biochemistry and Molecular Biology·Shiva Kumar AngalaMary Jackson
Jan 6, 2001·Memórias do Instituto Oswaldo Cruz·P H LagrangeJ L Herrmann
Jan 3, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Parasa V Ramana RaoAlamelu Raja
Jun 30, 2016·The Cochrane Database of Systematic Reviews·Liesl GroblerDavid Sinclair
Oct 19, 2007·FEMS Immunology and Medical Microbiology·Raj Kumar Verma, Amita Jain
Jun 25, 2015·Microbiology Spectrum·Mamadou DafféMary Jackson

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