Analysis of the influence of 4D MR angiography temporal resolution on time-to-peak estimation error for different cerebral vessel structures.

AJNR. American Journal of Neuroradiology
N D ForkertJ Fiehler

Abstract

Time-resolved MRA imaging is a promising technique for blood flow evaluation in case of cerebrovascular malformations. Unfortunately, 4D MRA imaging is a trade-off between spatial and temporal resolution. The aim of this study was to investigate the influence of temporal resolution on the error associated with TTP estimation from indicator dilution curves derived from different vascular structures. Monte Carlo simulation was performed to compute indicator dilution curves with known criterion standard TTP at temporal resolutions between 0.1 and 5 seconds. TTPs were estimated directly and by using 4 hemodynamic models for each curve and were compared with criterion standard TTP. Furthermore, clinical evaluation was performed by using 226 indicator dilution curves from different vessel structures obtained from clinical datasets. The temporal resolution was artificially decreased, and TTPs were estimated and compared with those obtained at the original temporal resolutions. The results of the clinical evaluations were further stratified for different vessel structures. The results of both evaluations show that the TTP estimation error increases exponentially when one lowers the temporal resolution. TTP estimation by using hemodynam...Continue Reading

References

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