Analysis of the influence of imaging-related uncertainties on cerebral aneurysm deformation quantification using a no-deformation physical flow phantom

Scientific Reports
Daniel ScheteligRené Werner

Abstract

Cardiac-cycle related pulsatile aneurysm motion and deformation is assumed to provide valuable information for assessing cerebral aneurysm rupture risk. Accordingly, numerous studies addressed quantification of cerebral aneurysm wall motion and deformation. Most of them utilized in vivo imaging data, but image-based aneurysm deformation quantification is subject to pronounced uncertainties: unknown ground-truth deformation; image resolution in the order of the expected deformation; direct interplay between contrast agent inflow and image intensity. To analyze the impact of the uncertainties on deformation quantification, a multi-imaging modality ground-truth phantom study is performed. A physical flow phantom was designed that allowed simulating pulsatile flow through a variety of modeled cerebral vascular structures. The phantom was imaged using different modalities [MRI, CT, 3D-RA] and mimicking physiologically realistic flow conditions. Resulting image data was analyzed by an established registration-based approach for automated wall motion quantification. The data reveals severe dependency between contrast media inflow-related image intensity changes and the extent of estimated wall deformation. The study illustrates that i...Continue Reading

References

Jun 1, 1993·Journal of Neurosurgery·F B MeyerS S Riederer
Jan 28, 1998·Stroke; a Journal of Cerebral Circulation·G J RinkelJ van Gijn
Jul 18, 2003·Lancet·David O WiebersUNKNOWN International Study of Unruptured Intracranial Aneurysms Investigators
Mar 16, 2007·Medical Image Computing and Computer-assisted Intervention : MICCAI·Laura Dempere-MarcoJuan Cebral
Jun 1, 2007·Journal of Vascular and Interventional Radiology : JVIR·Vahid YaghmaiMatthew T Walker
Oct 28, 2009·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·C KarmonikR Klucznik
Nov 20, 2009·IEEE Transactions on Medical Imaging·Stefan KleinJosien P W Pluim
Jul 24, 2010·Physiological Measurement·E OubelA F Frangi
Jan 29, 2011·Stroke; a Journal of Cerebral Circulation·Yasuyuki UmedaWaro Taki
Feb 26, 2011·AJNR. American Journal of Neuroradiology·T NishidaT Yoshimine
Jun 29, 2012·The New England Journal of Medicine·Akio MoritaTakashi Yoshimoto
Aug 14, 2012·Academic Radiology·Azadeh FirouzianWiro J Niessen
Feb 15, 2013·Cerebrovascular Diseases·Thorsten SteinerUNKNOWN European Stroke Organization
Mar 2, 2013·Stroke; a Journal of Cerebral Circulation·Jennifer S McDonaldHarry J Cloft
May 2, 2015·AJNR. American Journal of Neuroradiology·A E VanrossommeK Zouaoui Boudjeltia

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Citations

Mar 23, 2019·Scientific Reports·Maik LieblFrank Wiekhorst
May 5, 2021·Scientific Reports·Axel E VanrossommeKarim Zouaoui Boudjeltia

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