Analysis of the interaction effect of 48 SNPs and obesity on type 2 diabetes in Chinese Hans.
Abstract
Both environmental and genetic factors contribute to type 2 diabetes (T2D) risk. Dozens of T2D susceptibility loci have been identified by genome-wide association study. However, these loci account for only a small fraction of the familial T2D risk. We hypothesized that the gene-obesity interaction may contribute to the missing heritability. Forty-eight T2D-associated variants were genotyped using the TaqMan OpenArray Genotyping System and iPLEX Sequenom MassARRAY platform in two separate studies. Obesity was defined according to multiple indexes (body mass index (BMI), waist circumference and waist-hip ratio). Multiplicative interactions were tested using general logistic regression to assess the gene-obesity interaction effect on T2D risk among a total of 6206 Chinese Hans. After adjusting for the main effects of genes and obesity, as well as covariates (age, sex, smoking and alcohol consumption status), robust multiplicative interaction effects were observed between rs10811661 in CDKN2A/CDKN2B and multiple obesity indices (p ranged from 0.001 to 0.043 for BMI, waist circumference and waist-hip ratio). Obese individuals with the TT genotype had a drastically higher risk of T2D than normal weight individuals without the risk a...Continue Reading
References
The prediction of abdominal visceral fat level from body composition and anthropometry: ROC analysis
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Methods Mentioned
Software Mentioned
Related Concepts
Related Feeds
American Diabetes Association Journals
Discover the latest diabetes research published by the journals from the American Diabetes Association.