Analysis of the local kinetics and localization of interleukin-1 alpha, tumour necrosis factor-alpha and transforming growth factor-beta, during the course of experimental pulmonary tuberculosis

Immunology
Rogelio Hernández-PandoV Madrid-Marina

Abstract

A mouse model of pulmonary tuberculosis induced by the intratracheal instillation of live and virulent mycobacteria strain H37-Rv was used to examine the relationship of the histopathological findings with the local kinetics production and cellular distribution of tumour necrosis factor-alpha (TNF-alpha), interleukin-1 alpha (IL-1 alpha) and transforming growth factor-beta (TGF-beta). The histopathological and immunological studies showed two phases of the disease: acute or early and chronic or advanced. The acute phase was characterized by inflammatory infiltrate in the alveolar-capillary interstitium, blood vessels and bronchial wall with formation of granulomas. During this acute phase, which lasted from 1 to 28 days, high percentages of TNF-alpha and IL-1 alpha immunostained activated macrophages were observed principally in the interstium-intralveolar inflammatory infiltrate and in granulomas. Electron microscopy studies of these cells, showed extensive rough endoplasmic reticulum, numerous lysosomes and occasional mycobacteria. Double labelling with colloid gold showed that TNF-alpha and IL-1 alpha were present in the same cells, but were confined to separate vacuoles near the Golgi area, and mixed in larger vacuoles near...Continue Reading

References

Jan 1, 1990·European Journal of Immunology·L J MurrayC Martens
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S M WahlM B Sporn
Jun 1, 1986·The Journal of Experimental Medicine·C A DinarelloJ V O'Connor
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
Mar 1, 1994·Molecular and Cellular Endocrinology·A K StankovicC R Parker
Sep 27, 1993·Journal of Immunological Methods·S L ReinerR M Locksley

❮ Previous
Next ❯

Citations

Aug 27, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Rogelio Hernandez-PandoDiana Aguilar
Mar 24, 2005·Microbes and Infection·Andrew Evan WilliamsTracy Hussell
Feb 22, 2003·Experimental Parasitology·Laura Rivero-NavaJesús Calderón
May 9, 2000·FEMS Immunology and Medical Microbiology·A S PacsaA S Mustafa
Jun 24, 2000·FEMS Immunology and Medical Microbiology·U C ChaturvediA S Mustafa
Jul 11, 2002·Microbes and Infection·Kurt A Heldwein, Matthew J Fenton
Dec 28, 1999·Microbes and Infection·G R Strohmeier, M J Fenton
Apr 24, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dulce A Mata-EspinosaRogelio Hernández-Pando
Jun 20, 2002·The British Journal of Dermatology·K JayasankarV D Ramanathan
Jun 6, 2002·Immunology·Javier Rangel MorenoRogelio Hernández Pando
Aug 18, 2000·Immunology and Cell Biology·C Demangel, W J Britton
Jun 16, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tülin CağatayPenbe Cağatay
Oct 9, 2013·BMC Complementary and Alternative Medicine·Adelina Jiménez-ArellanesRogelio Hernández-Pando
Apr 12, 2014·PloS One·Estela Isabel BiniRogelio Hernández Pando
Feb 22, 2012·Immunotherapy·Mercedes Gonzalez-Juarrero
Jan 21, 2016·Tuberculosis·Jesus F Rangel-SantiagoSara Huerta-Yepez
Jul 4, 2012·Immunobiology·Gina S Garcia-RomoLeopoldo Flores-Romo
Jan 12, 2016·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Andreia Vieira PereiraBenedito Barraviera
Nov 22, 2011·European Journal of Medicinal Chemistry·Ricardo FigueiredoMaria do Céu Costa
Feb 5, 2008·Comparative Immunology, Microbiology and Infectious Diseases·María MuñozValentín Pérez
Apr 17, 2004·Clinical and Experimental Immunology·R A FabreS Estrada Parra
Jun 15, 2007·Journal of Biomedical Materials Research. Part a·D T LuttikhuizenM J A van Luyn
Nov 28, 2008·The Journal of Gene Medicine·Carlos Rodrigo Zárate-BladésCelio Lopes Silva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.