PMID: 9420627Jan 8, 1998Paper

Analysis of the MHC class I antigen presentation machinery in human embryonal carcinomas: evidence for deficiencies in TAP, LMP and MHC class I expression and their upregulation by IFN-gamma

Scandinavian Journal of Immunology
B SeligerH J Schmoll

Abstract

The expression of the major histocompatibility complex (MHC) class I antigens is suppressed in early post-implantation embryonic cells as well as in embryonal carcinoma (EC) cells, but could be upregulated by treatment with interferon (IFN)-gamma or retinoic acid. In a number of human and murine tumours, defects in the expression of the different components of the MHC class I antigen processing machinery, such as the proteasomal subunits LMP-2 and LMP-7 and the peptide transporters TAP-1 and TAP-2, account for impaired MHC class I surface expression. Here, we analysed the constitutive and IFN-gamma regulated mRNA and protein expression of the LMP, TAP and MHC class I molecules in the human EC line 577LM. In comparison to lymphoblastoid control cells, poor constitutive mRNA and protein expression of LMP-7, TAP-1, HLA class I, and beta 2-microglobulin, but not of TAP-2 and LMP-2, was detected in 577LM cells. The lack of MHC class I surface expression on 577LM cells could not be enhanced either by culturing cells at low temperature or by their incubation with exogenous MHC class I specific binding peptides: thus, the defective MHC class I surface expression was not only caused by impaired generation and processing of antigenic pep...Continue Reading

Citations

Aug 24, 1999·Medical Oncology·F Salazar-Onfray
May 30, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Stefan A DupontMarie Green
Sep 30, 2005·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M K KashyapS K Upadhyaya
Apr 17, 2012·Developmental and Comparative Immunology·Lv-yun ZhuJian-zhong Shao
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Nov 17, 2009·Western Journal of Nursing Research·Wen-Chii TzengJia-Fu Lee
Sep 3, 2016·Oncotarget·Barbara SeligerArndt Hartmann
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Oct 9, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Trevor E AngellAlan L Epstein

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