Analysis of the polymorphic variants of RAN and GEMIN3 genes and risk of Primary Open-Angle Glaucoma in the Polish population

Ophthalmic Genetics
Milena MolasyIreneusz Majsterek

Abstract

Glaucoma is considered as a neurodegenerative disorder in which the optic nerve damage leads to irreversible blindness. Many scientific findings indicate miRNA implication in the neurodegeneration process. In this study, we aimed to evaluate the polymorphic variants of miRNA processing genes, RAN (rs14035) and GEMIN3 (rs197388), and their association with a risk of primary open-angle glaucoma (POAG) in relation to selected clinical parameters. The study included 246 POAG patients and 188 controls. The selected gene polymorphisms were analyzed by TaqMan SNP Genotyping Assay using DNA extracted from blood samples. The obtained results indicated that the AA genotype of rs197388 as well as the A allele in the same gene may be associated with an elevated risk of POAG development (P = 0.021, P = 0.017 respectively). The correlation between the data and clinical parameters has shown that the A allele of rs197388 in relation to retinal nerve fiber layer(RNFL) could be responsible for an increased risk of glaucoma occurrence (P = 0.028), while the AT genotype could be associated with a decreased risk of POAG according to the mean deviation parameter (P = 0.023). Our data has shown that GEMIN3 gene (rs197388) polymorphisms might be assoc...Continue Reading

References

Feb 21, 2006·The British Journal of Ophthalmology·H A Quigley, A T Broman
Mar 1, 2006·Investigative Ophthalmology & Visual Science·Michael R SteeleMonica L Vetter
Sep 1, 2007·Science·Sébastien S Hébert, Bart De Strooper
Dec 9, 2008·Experimental Eye Research·R Rand AllinghamDouglas J Rhee
Mar 4, 2009·Nature Cell Biology·Julia WinterSven Diederichs
Dec 17, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Li LiHongfei Wang
Jan 8, 2010·BMC Developmental Biology·Amit AroraDavid A Simpson
Jan 8, 2010·Investigative Ophthalmology & Visual Science·Guorong LiPedro Gonzalez
Feb 23, 2010·Genomics, Proteomics & Bioinformatics·Yimei CaiJun Yu
Oct 28, 2010·Genomics·Brian C Schanen, Xiaoman Li
Feb 1, 2011·Journal of Molecular Cell Biology·Liqin Du, Alexander Pertsemlidis
Feb 19, 2011·Investigative Ophthalmology & Visual Science·Guadalupe VillarrealDouglas J Rhee
Apr 5, 2011·Mutation Research·Maria I AlmeidaGeorge A Calin
Sep 21, 2011·Investigative Ophthalmology & Visual Science·Cristina Blanco-MarchiteJulio Escribano
Sep 29, 2011·Progress in Retinal and Eye Research·Manuel Vidal-SanzMaria P Villegas-Pérez
Dec 6, 2011·Nature Neuroscience·Marie-Laure BaudetChristine E Holt
Apr 18, 2012·Frontiers in Neuroscience·Eduardo Gascon, Fen-Biao Gao
Sep 24, 2013·Progress in Retinal and Eye Research·Sarah F JanssenArthur A B Bergen
Jan 7, 2014·Frontiers in Cellular Neuroscience·Simona MaciottaYvan Torrente
May 16, 2014·JAMA : the Journal of the American Medical Association·Robert N WeinrebFelipe A Medeiros
Oct 27, 2015·Progress in Brain Research·Giovanni Luca RomanoClaudio Bucolo
Dec 22, 2015·BioMed Research International·Ewa Osuch-WojcikiewiczIreneusz Majsterek
Jul 15, 2016·Journal of Human Genetics·Milena MolasyIreneusz Majsterek
Jan 11, 2017·Ophthalmic Research·Ruru GuoJiantao Wang

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.