Analysis of the possible protective role of metallothionein in streptozotocin-induced diabetes using metallothionein-null mice

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
M D ApostolovaC Tohyama

Abstract

In order to clarify a possible protective role of metallothionein (MT) in the development of streptozotocin (STZ)-caused insulin-dependent diabetes mellitus (IDDM) and its mechanisms, we studied whether MT is effective for protection against STZ-caused IDDM by utilizing MT-null (isoforms MT-I and II) transgenic mice. It was found that Zn pretreatment (I mg/kg body weight as ZnSO4) has a unique inhibitory effect on IDDM development in MT-null mice in contrast to no marked effect in control (C57BL/6J) mice, suggesting that Zn ions free from MT molecules exerted this protective effect. The highest Zn dose (10 mg/kg body weight) fully suppressed development of hyperglycaemia in both types of mice. Pretreatment with Zn partially led to recovery of superoxide dismutase activities in the liver and pancreas in which STZ administration suppressed superoxide dismutase activity in both types of mice. The present study suggests that Zn plays an important role in the pathogenesis of IDDM, although a possible involvement of MT in the protection of STZ-caused IDDM cannot be completely negated.

References

Nov 11, 1966·Biochemical and Biophysical Research Communications·J QuartermanW R Humphries
Jan 1, 1981·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·C Tohyama, Z A Shaikh
Aug 1, 1994·Biological Trace Element Research·J P Van Wouwe, J J Uijlenbroek
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·B A MastersR D Palmiter

❮ Previous
Next ❯

Citations

Sep 15, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Carla G Taylor
Oct 28, 2008·Biological Trace Element Research·Ming-Der Chen, Yuh-Min Song
Jan 7, 2014·Neurochemistry International·Sushil Sharma, Manuchair Ebadi
Jan 12, 1999·Mechanisms of Ageing and Development·E MocchegianiR Giacconi
Aug 15, 2000·Molecular and Cellular Endocrinology·S G LaychockC O Simpkins
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·J H BeattieP Trayhurn
Oct 22, 2008·The Journal of Nutrition·Meryl E Wastney, William A House
Feb 2, 2012·The Journal of Toxicological Sciences·Kyoumi NakazatoTakeaki Nagamine
May 20, 1999·Annual Review of Pharmacology and Toxicology·C D KlaassenS Choudhuri
Jun 16, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·E Canpolat, M A Lynes
Apr 1, 2004·Nonlinearity in Biology, Toxicology, Medicine·Lu Cai
Nov 15, 2005·Diabetes/metabolism Research and Reviews·Murat AyazBelma Turan
Apr 6, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masao Sato, Shinya Suzuki
Apr 6, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masahiko Satoh
Dec 7, 2007·BioFactors·Md Shahidul Islam, Du Toit Loots
Sep 27, 2013·Metallomics : Integrated Biometal Science·Martina RaudenskaMichal Masarik
Dec 25, 2004·Experimental Biology and Medicine·Jordan R OliverM George Cherian
Aug 28, 2003·Diabetes, Obesity & Metabolism·I K HwangM K Song
Mar 6, 2012·Diabetes/metabolism Research and Reviews·Daniel LazardKonstantin Bloch
Jul 17, 2012·Chemical Reviews·Kasper P Kepp

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.