Analysis of the proteomic profile of chronic pressure ulcers

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Laura E EdsbergKristin M Fries

Abstract

Analysis of the proteomic profile of pressure ulcers over time is a critical step in the identification of biomarkers of healing or nonhealing in pressure ulcers. The wound fluid from 32 subjects with 42 pressure ulcers was evaluated over 6 weeks at 15 time points. Samples specific to both the interior and the periphery of the wound bed were collected. Antibody screening arrays, isobaric tags for relative and absolute quantitation with mass spectrometry and multiplexed microarrays were used to characterize wound fluid and results were correlated with clinical outcome. Twenty-one proteins were found to distinguish between healed and chronic wounds and 19 proteins were differentially expressed between the interior and periphery of wounds. Four proteins, pyruvate kinase isozymes M1/M2, profilin-1, Ig lambda-1 chain C regions, and Ig gamma-1 chain C region, were present in lower levels for periphery samples when compared to interior samples and six proteins, keratin, type II cytoskeletal 6A (KRT6A), keratin, type I cytoskeletal 14, S100 calcium binding proteins A7, alpha-1-antitrypsin precursor, hemoglobin subunit alpha, and hemoglobin subunit beta, were present in higher levels in periphery samples when compared with interior samp...Continue Reading

References

Sep 28, 2000·Current Opinion in Chemical Biology·S P Gygi, R Aebersold
Sep 30, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·T J JamesR P Taylor
Mar 22, 2001·Biochemistry·M RuseR L Eckert
Jul 21, 2001·The Journal of Biological Chemistry·I S ThoreyS Werner
May 2, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Glenn P LadwigGregory S Schultz
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carle RyckmanPhilippe A Tessier
Jul 2, 2003·Thorax·D FoellJ Roth
Mar 25, 2004·Trends in Immunology·Paola RomagnaniSergio Romagnani
Jun 12, 2004·The Journal of Investigative Dermatology·Richard L EckertKathleen Lee
Jul 21, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ryan MoseleyDavid W Thomas
Sep 18, 2004·The American Journal of Cardiology·Fei YeToshio Miyawaki
Mar 22, 2006·American Journal of Nephrology·Michael C BraunJui-Yoa Chang
Apr 1, 1996·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·N J TrengoveM C Stacey
Jan 16, 2008·Sub-cellular Biochemistry·C W HeizmannA Galichet
Jan 20, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Shinji IizakaJunko Sugama
May 25, 2010·International Wound Journal·Jennifer T WyffelsLaura E Edsberg
Jun 5, 2010·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Kenneth HsuMark C Herzberg
Mar 3, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Gregory S SchultzIra M Herman
Sep 20, 2011·Advances in Skin & Wound Care·Jennifer T Wyffels, Laura E Edsberg

❮ Previous
Next ❯

Citations

Feb 15, 2014·Advances in Wound Care·Tomasz ArodzRobert F Diegelmann
Nov 7, 2013·Journal of Translational Medicine·Brett A ChromyPaul A Luciw
Mar 4, 2014·Journal of Materials Science. Materials in Medicine·Laura MayolGiuseppe De Rosa
Jun 12, 2014·Expert Review of Molecular Diagnostics·Ferdinando MannelloJoseph D Raffetto
Nov 30, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Arti V ShindePaula J McKeown-Longo
Dec 10, 2014·Journal of Proteome Research·Domenico TavernaLillian B Nanney
Jun 27, 2014·The Journal of Spinal Cord Medicine·Laura E EdsbergPamela Houghton
Dec 5, 2014·Science Translational Medicine·Sabine A EmingMarjana Tomic-Canic
Jul 8, 2016·Advanced Healthcare Materials·Subhamoy DasAaron B Baker
Aug 25, 2016·Plastic and Reconstructive Surgery·Linsey E LindleyMarjana Tomic-Canic
Jun 19, 2013·The International Journal of Lower Extremity Wounds·Markus W LöfflerStefan Beckert
Jun 5, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maria IliesElke Hammer
Oct 24, 2018·Expert Review of Proteomics·Cristina HerreraJosé María Gutiérrez
Jul 16, 2020·Advances in Wound Care·Paula J McKeown-Longo, Paul J Higgins
Dec 14, 2018·Physiological Measurement·Xi GaoRobert F Diegelmann
May 6, 2017·Journal of Orthopaedic Surgery and Research·Laura E EdsbergJennifer T Wyffels
Jul 9, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Luciana Patricia Fernandes AbbadeBenedito Barraviera
Nov 18, 2020·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Taichi Goto, Leorey N Saligan
May 23, 2021·Science Advances·Yuji GaoChwee Teck Lim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
T J JamesRichard P Taylor
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Andrea N MoorLisa J Gould
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Shinji IizakaJunko Sugama
© 2021 Meta ULC. All rights reserved