Analysis of the Smad2 gene in hematological malignancies

Leukemia
T IkezoeI Miyoshi

Abstract

A total of 34 leukemia and lymphoma samples (17 clinical samples and 17 cell lines) were analyzed for mutations of the Smad2 gene by reverse transcriptase-polymerase chain reaction single strand conformation polymorphism (RT-PCR-SSCP) analysis. Nine of the 34 samples had 18q chromosomal abnormalities. No shifted bands were detected in any of the hematological malignancies. Our results suggest that resistance to cell growth inhibitory effects of TGF-beta in hematological malignancies is not due to alterations of the Smad2 gene.

Citations

Feb 13, 2001·Journal of Cellular Physiology·B Pasche
Apr 1, 2008·Journal of Biosciences·Feng LiuYu-Yang Jiang
Feb 19, 2002·Oncogene·Junko H OhyashikiKazuma Ohyashiki
Apr 21, 2001·Oncogene·M M RosenkildeT W Schwartz
Jul 26, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Kenichi Nakayama, Toshihiro Nakamura
Mar 11, 1999·American Journal of Hematology·T IkezoeH Taguchi

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