Analysis of the time-to-onset of osteonecrosis of jaw with bisphosphonate treatment using the data from a spontaneous reporting system of adverse drug events

Journal of Pharmaceutical Health Care and Sciences
Mitsuhiro NakamuraYasutomi Kinosada

Abstract

Bisphosphonates (BPs) are potent antiresorptive agents used to treat osteoporosis and the complications associated with malignant bone metastasis. The aim of this study was to evaluate the incidence of bisphosphonate-related osteonecrosis of the jaw (BRONJ) using the Japanese Adverse Drug Event Report (JADER) database. In particular, we focused on the time-to-onset profile of BRONJ. We analyzed reports of BRONJ in the JADER database and calculated the reporting odds ratio (ROR) of BPs potentially associated with BRONJ. We applied the weibull shape parameter to time-to-event data in JADER. The drugs selected for this investigation were seven BPs approved in Japan (alendronate [intraveneous, I.V.], pamidronate, and zoledronate as I.V. BPs; and alendronate (oral), etidronate, minodronate, and risedronate as oral BPs). We analyzed reports of BRONJ events associated with BPs in the JADER database from April 2004 to November 2014. The median value of BRONJ cases caused by alendronate (I.V.), pamidronate, zoledronate, alendronate (oral), etidronate, minodronate, and risedronate were 1342, 812, 486, 863, 1461, 432, and 730 days, respectively. The lower 95 % confidence interval of the Weibull-shape parameter β for I.V. BPs (pamidronate ...Continue Reading

References

May 10, 2002·Pharmacoepidemiology and Drug Safety·Eugène P van PuijenbroekAntoine C G Egberts
May 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kathryn L KavanaghUdo Oppermann
Sep 24, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Joan C LoUNKNOWN Predicting Risk of Osteonecrosis of the Jaw with Oral Bisphosphonate Exposure (PROBE) Investigators
Dec 8, 2009·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Salvatore L RuggieroUNKNOWN Task Force on Bisphosphonate-Related Osteonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons
Jan 1, 2010·Drug, Healthcare and Patient Safety·Luca Dalle CarbonareMaria Teresa Valenti
Jul 26, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Masahiro UradeJinichi Fukuta
Jun 19, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Victoria R CorneliusStephen J W Evans
May 16, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Odile SauzetVictoria R Cornelius
Aug 2, 2013·Therapeutic Advances in Musculoskeletal Disease·Ieva RuzaUgis Gruntmanis
Sep 23, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Salvatore L RuggieroFelice O'Ryan
Jan 29, 2016·Journal of Pharmaceutical Health Care and Sciences·Yamato KatoMitsuhiro Nakamura

❮ Previous
Next ❯

Citations

Jun 2, 2017·Biological & Pharmaceutical Bulletin·Ayako HaraJunko Kizu
Dec 5, 2017·Biological & Pharmaceutical Bulletin·Satoshi NakaoMitsuhiro Nakamura
Oct 3, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Shiori HasegawaMitsuhiro Nakamura
Aug 11, 2019·Journal of Clinical Pharmacy and Therapeutics·Sayoko KinoshitaMitsutaka Takada
Dec 7, 2018·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Fusao KomadaKohji Takara
Jul 22, 2017·Journal of Pharmaceutical Health Care and Sciences·Haruna HatahiraMitsuhiro Nakamura
Feb 2, 2018·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Fusao Komada
Jan 1, 2017·Therapeutic Innovation & Regulatory Science·Yomei Matsuoka, Mamoru Narukawa
Jun 23, 2016·Journal of Pharmaceutical Health Care and Sciences·Junko AbeMitsuhiro Nakamura
Feb 6, 2019·Journal of Bone and Mineral Metabolism·Akira TaguchiUNKNOWN Adequate Treatment of Osteoporosis (A-TOP) research group
Oct 7, 2017·The Cochrane Database of Systematic Reviews·Natalie H Beth-TasdoganOliver Zolk
Sep 24, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Guang YangYan Gong
Feb 16, 2021·Journal of Maxillofacial and Oral Surgery·Sabit Demircan, S Cemil İşler

❮ Previous
Next ❯

Software Mentioned

BRONJ
JMP
WSP
JADER

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Xiaoyan ZhangYan Gong
Hormones : International Journal of Endocrinology and Metabolism
Athanasios D AnastasilakisAvraam Avramidis
Journal of Periodontal & Implant Science
Eun-Young ShinJong-Hyuk Chung
© 2021 Meta ULC. All rights reserved