Analysis of the transcriptional activity of genes of neuropeptides and their receptors in the blood of patients with thyroid pathology.

Journal of Medicine and Life
Iryna Ivanivna KamyshnaAleksandr M Kamyshnyi

Abstract

The thyroid hormone plays a vital role in the development and maturation of the nervous system not only during prenatal and perinatal age but also in adults. "Peripheral marker hypothesis" revealed that gene expression changes in some regions of the brain are reflected into the peripheral blood lymphocytes. The objective of the study was to investigate changes in the gene expression profile of neuropeptides and their receptors in patients with different forms of thyroid pathology. One hundred fifty-three patients with thyroid pathology were enrolled in the study. They were divided into three groups: group 1 included 16 patients with postoperative hypothyroidism, group 2 included 65 patients with hypothyroidism resulting from autoimmune thyroiditis (AIT), and group 3 included 72 patients with AIT and elevated levels of anti-thyroglobulin (anti-Tg) and anti-thyroid peroxidase (anti-TPO) antibodies in the serum. We used a pathway-specific polymerase chain reaction (PCR) array (RT2 Profiler™ PCR Array Human Neurotrophins & Receptors, QIAGEN, Germany) to identify and verify neuropeptides and receptors pathway-focused gene expression in 12 individuals that were randomly selected from each group using real-time PCR. Our research ident...Continue Reading

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Citations

Oct 9, 2021·Journal of Medicine and Life·Iryna Ivanivna KamyshnaAleksandr Mychailovich Kamyshnyi

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Software Mentioned

RT 2 Profiler PCR Array
RT 2 Profiler PCR Array Data Analysis
plot
Cell
RT 2 Profiler
STAT
NucleoZOL
QIAGEN
GeneGlobe

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