Analysis of TP53 mutations in relapsed childhood acute lymphoblastic leukemia

Journal of Pediatric Hematology/oncology
J GumpStephen P Hunger


TP53 is the most commonly mutated gene in human cancer, but TP53 mutations are present in less than 5% of children with acute lymphoblastic leukemia (ALL) at initial presentation. Mutations are detected more frequently in children with relapsed T-cell ALL, but the potential role of TP53 mutations in relapsed B-lineage childhood ALL is not understood as well. The authors determined the nucleotide sequence of amplified DNA from exons 5 to 8 of the TP53 gene in leukemic cells obtained from 17 children with ALL at the time of first bone marrow relapse. All 17 contained only germline TP53 sequences. Review of the published literature disclosed that TP53 mutations have been found in 22% of cases of relapsed ALL. To understand the role of p53 abnormalities in this clinical setting, it will be important for future studies to analyze cases of relapsed ALL with assays capable of interrogating the functional integrity of the p53 pathway.


Feb 1, 1992·The Journal of Clinical Investigation·C A FelixJ Whang-Peng
Apr 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C PreudhommeB Gosselin
Jan 1, 1993·Leukemia & Lymphoma·V Gandhi
Dec 1, 1995·Leukemia Research·K SchwenkeL E Feinendegen
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D I MarksD S Haines
May 15, 1997·Nature·Y HauptM Oren
May 15, 1997·Nature·M H KubbutatK H Vousden

❮ Previous
Next ❯


Jun 6, 2009·Blood·Valeria ToselloAdolfo A Ferrando
Dec 1, 2011·Best Practice & Research. Clinical Haematology·Charles G Mullighan
Oct 31, 2006·British Journal of Haematology·Gino BoilyDaniel Sinnett
Mar 4, 2010·Cytometry. Part B, Clinical Cytometry·Geraldo Barroso CavalcantiRaquel Ciuvalschi Maia
Mar 18, 2015·Nature Reviews. Clinical Oncology·Kathryn G Roberts, Charles G Mullighan
Jan 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Majid SafaAhmad Kazemi
Jul 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jana HofRenate Kirschner-Schwabe
Dec 23, 2016·Cold Spring Harbor Perspectives in Medicine·Evan Q Comeaux, Charles G Mullighan
Nov 25, 2003·Hematology·William L CarrollJohn C Reed
Nov 5, 2011·Journal of Nursing Management·Evridiki PapastavrouRiitta Suhonen
Nov 16, 2019·Cancer Science·Chih-Hsiang YuYung-Li Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.