PMID: 15222779Jun 30, 2004Paper

Analysis of translocations in stable cells and their implications in retrospective biological dosimetry

Radiation Research
P RodríguezL Barrios

Abstract

The aim of the present study was to evaluate the influence of the exclusion of cells with unstable aberrations in the elaboration of dose-effect curves for translocations and their implications in biological dosimetry of past exposures. To establish dose-effect curves, peripheral blood samples were irradiated with 60Co gamma rays at ten different doses and the yield of translocations analyzed by FISH was considered in all cells and in stable cells (those without dicentrics, acentrics or rings). To discriminate transmissible translocations, the dose- effect curve for total apparently simple translocations in stable cells was chosen as the reference. In stable cells, dose- effect curves for apparently simple translocations without pseudosimple and complex-derived one-way patterns, tAbtBa and total translocations were obtained. None of these curves differed from the reference curve. When all cells were considered, only the curve for total translocations was significantly different from the reference curve. From the results obtained it can be concluded that the use of dose-effect curves for apparently simple translocations in stable cells and in all cells will give similar dose estimates in retrospective biological dosimetry studie...Continue Reading

References

Jul 1, 1992·International Journal of Radiation Biology·J N LucasJ Gray
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N E Morton
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D PinkelJ W Gray
Jan 1, 1995·Cytogenetics and Cell Genetics·J D TuckerC Shasserre
Nov 1, 1996·Mutation Research·J R Savage, J D Tucker
Mar 7, 1998·International Journal of Radiation Biology·S KnehrM Bauchinger
Dec 16, 1998·International Journal of Radiation Biology·C LindholmS Salomaa
Jan 6, 2000·International Journal of Radiation Biology·J F BarquineroL Barrios
May 31, 2001·International Journal of Radiation Biology·M BauchingerH Braselmann
Apr 23, 2002·Radiation Research·Shea N Gardner, James D Tucker

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Citations

Jul 10, 2010·Radiation and Environmental Biophysics·Marcela Maria Pereira de Lemos PintoAdemir Amaral
Aug 3, 2006·International Journal of Radiation Biology·E GregoireL Roy
Mar 27, 2016·Radiation and Environmental Biophysics·Gordon K LivingstonSatoshi Tashiro
Jun 28, 2008·Radiation Research·M MestresJ F Barquinero
Apr 29, 2009·Radiation Research·Assumpta DuranLeonardo Barrios
Oct 6, 2016·International Journal of Radiation Biology·Joan Francesc BarquineroLeonardo Barrios
Jan 26, 2011·Attention, Perception & Psychophysics·Meghan M McConnell, David I Shore
Dec 2, 2004·Radiation Protection Dosimetry·A V Sevan'kaevJ F Barquinero
Jun 2, 2005·Radiation Protection Dosimetry·A A EdwardsP Voisin

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