Analysis of treatment success with new inclusion criteria for antibiotic therapy for uncomplicated appendicitis: A multicentre cohort study.

International Journal of Clinical Practice
Sung Sil ParkHyoung Chul Park

Abstract

Conservative antibiotic treatment for uncomplicated appendicitis is debated because of the unproven criteria for use and relatively high failure rate. We developed inclusion criteria to optimize antibiotic therapy use and compared the success rate to that seen in previous literature. Our antibiotic therapy inclusion criteria were developed based on clinical findings (symptom onset ≤48 hours and body temperature ≤38.3℃), laboratory parameters (white blood cell count ≤12000/mL) and radiologic findings (appendiceal diameter ≤12 mm and no appendicolith). Patients who met inclusion criteria were enrolled from three hospitals between 2016 and 2017. Treatment success was defined as a response to antibiotic therapy and no recurrent symptoms within 1 year. We compared our success rate with previous clinical trial success rates. There were 240 patients enrolled (116 men and 124 women) with a mean age of 38.7 years. After initial antibiotic treatment, 233 patients (97.1%) responded to therapy and were discharged. There were no post-treatment complications with Clavien-Dindo grade ≥III. During the 1-year follow-up period, the treatment success rate was 88.8% (213/240) and the recurrence rate was 8.6% (20/233; 15 underwent surgery and 5 rec...Continue Reading

References

Feb 1, 1995·The British Journal of Surgery·S Eriksson, L Granström
Jul 2, 2003·Annals of Surgery·Julie A MargenthalerShukri F Khuri
Jul 23, 2005·AJR. American Journal of Roentgenology·Nuno Pinto LeiteClaude Sirlin
Jun 30, 2009·Annals of Surgery·Terry T W LeungAnthony R MacLean
Jul 16, 2014·International Journal of Surgery·Hyoung-Chul ParkBong Hwa Lee
Jun 17, 2015·JAMA : the Journal of the American Medical Association·Paulina SalminenJuha M Grönroos
Oct 6, 2015·The Journal of Surgical Research·Ramon R GorterJohanna H van der Lee
Sep 20, 2017·The British Journal of Surgery·H C ParkB H Lee
Nov 18, 2017·The Journal of Surgical Research·Tyler J LoftusJaneen R Jordan

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