Analysis of tricyclic antidepressant drugs in plasma and serum by chromatographic techniques

Journal of Chromatography
T R Norman, K P Maguire

Abstract

A review of methods for the determination of tricyclic antidepressants in plasma or serum, based on the application of chromatographic techniques, is presented. A general discussion of the techniques in terms of their precision, accuracy, sensitivity and selectivity, with respect to parent drug and metabolites, is used to facilitate a comparison of methods. No one technique can be claimed as the method of choice for these drugs, although gas-liquid chromatography with nitrogen selective detection has some strong claims, viz. generally good sensitivity and reproducibility of assays and ready availability of equipment in most laboratories. The ultimate choice of a method for determining tricyclics will be determined more by the clinical application (routine monitoring versus pharmacokinetics) than by other factors.

References

Jul 1, 1977·Clinical Pharmacokinetics·L F Gram
May 1, 1978·The American Journal of Psychiatry·M LinnoilaK Jobson
Aug 1, 1978·Biochemical Medicine·G D BurrowsJ Burch
Jan 1, 1979·Drug Metabolism Reviews·R Gupta, G Molnar
Feb 1, 1979·Journal of Pharmaceutical Sciences·T B Cooper, R G Kelly
Aug 1, 1979·British Journal of Clinical Pharmacology·T R NormanJ M Wurm
Oct 15, 1979·European Journal of Pharmacology·R B InnisS H Snyder
Dec 1, 1979·Journal of Pharmaceutical Sciences·U W Wiegand, G Levy
Sep 1, 1977·Journal of Chromatography·G Nyberg, E Mårtensson
Feb 1, 1977·Clinical Biochemistry·H BruderleinD Dvornik
Apr 11, 1977·Journal of Chromatography·T R NormanG D Burrows
Jan 25, 1978·Archives of Toxicology·H P GelbkeG Schmidt
Jun 1, 1978·Journal of Pharmaceutical Sciences·M T RosseelM Claeys
Sep 21, 1978·Journal of Chromatography·B Mellström, R Braithwaite
Jan 1, 1979·Clinical Pharmacology and Therapeutics·M WoodA J Wood
Jul 1, 1976·Journal of Pharmaceutical Sciences·J E O'Brien, O N Hinsvark
Nov 17, 1976·Journal of Chromatography·M R DetaevernierD L Massart

❮ Previous
Next ❯

Citations

Apr 13, 2007·Analytical and Bioanalytical Chemistry·Frank T Peters
Sep 1, 1994·The American Journal of Emergency Medicine·J G SchwartzJ J Carnahan
Jul 2, 2004·Therapeutic Drug Monitoring·Finn Bengtsson
May 8, 1992·Journal of Chromatography·R N Gupta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.