Analysis of tricyclic antidepressant drugs in plasma and serum by chromatographic techniques

Journal of Chromatography
T R Norman, K P Maguire


A review of methods for the determination of tricyclic antidepressants in plasma or serum, based on the application of chromatographic techniques, is presented. A general discussion of the techniques in terms of their precision, accuracy, sensitivity and selectivity, with respect to parent drug and metabolites, is used to facilitate a comparison of methods. No one technique can be claimed as the method of choice for these drugs, although gas-liquid chromatography with nitrogen selective detection has some strong claims, viz. generally good sensitivity and reproducibility of assays and ready availability of equipment in most laboratories. The ultimate choice of a method for determining tricyclics will be determined more by the clinical application (routine monitoring versus pharmacokinetics) than by other factors.


Jul 1, 1977·Clinical Pharmacokinetics·L F Gram
May 1, 1978·The American Journal of Psychiatry·M LinnoilaK Jobson
Aug 1, 1978·Biochemical Medicine·G D BurrowsJ Burch
Jan 1, 1979·Drug Metabolism Reviews·R Gupta, G Molnar
Feb 1, 1979·Journal of Pharmaceutical Sciences·T B Cooper, R G Kelly
Aug 1, 1979·British Journal of Clinical Pharmacology·T R NormanJ M Wurm
Oct 15, 1979·European Journal of Pharmacology·R B InnisS H Snyder
Dec 1, 1979·Journal of Pharmaceutical Sciences·U W Wiegand, G Levy
Sep 1, 1977·Journal of Chromatography·G Nyberg, E Mårtensson
Feb 1, 1977·Clinical Biochemistry·H BruderleinD Dvornik
Apr 11, 1977·Journal of Chromatography·T R NormanG D Burrows
Jan 25, 1978·Archives of Toxicology·H P GelbkeG Schmidt
Jun 1, 1978·Journal of Pharmaceutical Sciences·M T RosseelM Claeys
Sep 21, 1978·Journal of Chromatography·B Mellström, R Braithwaite
Jan 1, 1979·Clinical Pharmacology and Therapeutics·M WoodA J Wood
Jul 1, 1976·Journal of Pharmaceutical Sciences·J E O'Brien, O N Hinsvark
Nov 17, 1976·Journal of Chromatography·M R DetaevernierD L Massart

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Apr 13, 2007·Analytical and Bioanalytical Chemistry·Frank T Peters
Sep 1, 1994·The American Journal of Emergency Medicine·J G SchwartzJ J Carnahan
Jul 2, 2004·Therapeutic Drug Monitoring·Finn Bengtsson
May 8, 1992·Journal of Chromatography·R N Gupta

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