PMID: 6978913Feb 1, 1982Paper

Analysis of unexpected inhibitions of T lymphocyte proliferation to soluble antigen, alloantigen and mitogen by unfragmented anti-I-Ak or anti-I-E/Ck monoclonal antibodies

Journal of Immunogenetics
P C DubreuilF A Lemonnier

Abstract

We investigated the capacity of anti-I-Ak and anti-I-E/Ck monoclonal antibodies (m.Ab.) to inhibit T lymphocyte proliferative responses to soluble antigen (Keyhole limpet hemocyanin), alloantigens (H-2 or non-H-2 related) and a mitogen (Concanavalin A). Surprisingly, specific inhibition was observed in all circumstances, and with both anti-I-Ak and anti-I-E/Ck m.Ab., whether the responses tested were I restricted in cell mixing experiments or not. The significance of the inhibition by anti-Ia m.Ab. of non-Ia-restricted responses is still not completely understood. These results, however, strongly suggest that in vitro inhibition by anti-Ia antibodies of T cell proliferative responses does not necessarily indicate I restriction of the presentation to T lymphocytes of the corresponding antigen.

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Citations

Feb 1, 1988·Journal of Immunogenetics·C A JanewayS Buxser
Feb 1, 1989·Immunological Reviews·C A JanewayS Buxser
Feb 1, 1988·Journal of Immunogenetics·B Frangoulis, J Klein
Feb 1, 1989·Immunological Reviews·S R Webb, J Sprent
Aug 1, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katharine M IrvineMatthew J Sweet
Sep 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ji QiuSamir M Hanash
Nov 14, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J AlexanderA Sher
Feb 1, 1994·Journal of the Royal Army Medical Corps·J M Sloss, C A Pailthorpe
Feb 1, 1983·European Journal of Immunology·H Von Boehmer, K Turton
Feb 1, 1988·Journal of Immunogenetics·R H DeKruyffM E Dorf

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