Analysis of vascular endothelial growth factor gene 936 C/T polymorphism in patients with familial Mediterranean fever

International Journal of Immunogenetics
Ramazan GünesacarD Deveci

Abstract

Vascular endothelial growth factor (VEGF) is a cytokine that promotes endothelial cell proliferation, leucocyte chemotaxis and expression of adhesion molecules and is a major mediator of vascular permeability. It has been demonstrated that VEGF directly activates neutrophils and it could promote acute recruitment of leucocytes. It is known that neutrophils are the major cell population involved in acute inflammation in familial Mediterranean fever (FMF) and the role of VEGF in these cells may be crucial. The aim of this study was to investigate whether the 936 C/T functional polymorphism of the VEGF gene is associated with susceptibility to FMF and its relationship with the main clinical features of the disease. Polymerase chain reaction-restriction fragment length polymorphism technique was used to determine 936 C/T polymorphism within the VEGF gene in 75 patients with FMF and 122 non-related healthy controls. Genotype and allele frequencies of the VEGF 936 C/T polymorphism between patients with FMF and healthy control groups were not significantly different (OR = 0.74, 95% CI = 0.40-1.37, P = 0.335 for CT genotype; OR = 1.11, 95% CI = 0.67-1.83, P = 0.700, for T allele). Although VEGF 936 TT genotype was found to be more freq...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Aug 1, 1967·The American Journal of Medicine·E SoharH Heller
Sep 1, 1997·Nature Genetics·UNKNOWN French FMF Consortium
Oct 23, 1997·Arthritis and Rheumatism·A LivnehM Pras
Jan 30, 2002·Acta Haematologica·N Ferrara, H P Gerber
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Peter KripplHellmut Samonigg
Jan 12, 2005·Medicine·Mehmet TuncaUNKNOWN Turkish FMF Study Group
Jul 5, 2006·Journal of Leukocyte Biology·Sandra I Zittermann, Andrew C Issekutz

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Citations

Apr 3, 2010·The Open Cardiovascular Medicine Journal·Sahru YükselArmen Yuri Gasparyan
Jan 4, 2010·Macromolecular Rapid Communications·Paul Brochu, Qibing Pei

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