Abstract
Vascular endothelial growth factor (VEGF) is a cytokine that promotes endothelial cell proliferation, leucocyte chemotaxis and expression of adhesion molecules and is a major mediator of vascular permeability. It has been demonstrated that VEGF directly activates neutrophils and it could promote acute recruitment of leucocytes. It is known that neutrophils are the major cell population involved in acute inflammation in familial Mediterranean fever (FMF) and the role of VEGF in these cells may be crucial. The aim of this study was to investigate whether the 936 C/T functional polymorphism of the VEGF gene is associated with susceptibility to FMF and its relationship with the main clinical features of the disease. Polymerase chain reaction-restriction fragment length polymorphism technique was used to determine 936 C/T polymorphism within the VEGF gene in 75 patients with FMF and 122 non-related healthy controls. Genotype and allele frequencies of the VEGF 936 C/T polymorphism between patients with FMF and healthy control groups were not significantly different (OR = 0.74, 95% CI = 0.40-1.37, P = 0.335 for CT genotype; OR = 1.11, 95% CI = 0.67-1.83, P = 0.700, for T allele). Although VEGF 936 TT genotype was found to be more freq...Continue Reading
References
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Aug 1, 1967·The American Journal of Medicine·E SoharH Heller
Sep 1, 1997·Nature Genetics·UNKNOWN French FMF Consortium
Oct 23, 1997·Arthritis and Rheumatism·A LivnehM Pras
Jul 17, 1998·The Journal of Investigative Dermatology·M DetmarR K Jain
Jan 8, 2000·Human Immunology·I J BroganI V Hutchinson
Aug 10, 2000·Cytokine·C J WatsonP E Brenchley
Jan 9, 2001·Journal of Vascular Research·W RennerE Pilger
Jan 30, 2002·Acta Haematologica·N Ferrara, H P Gerber
Apr 30, 2002·Diabetes·Takuya AwataShigehiro Katayama
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Peter KripplHellmut Samonigg
Jun 24, 2004·Rheumatology·S W HanY M Kang
Jan 12, 2005·Medicine·Mehmet TuncaUNKNOWN Turkish FMF Study Group
Jul 15, 2005·Rheumatology·J S SeoY M Kang
Oct 18, 2005·Genetic Testing·Ramazan GunesacarHuseyin T E Ozer
Jul 5, 2006·Journal of Leukocyte Biology·Sandra I Zittermann, Andrew C Issekutz
Citations
Apr 3, 2010·The Open Cardiovascular Medicine Journal·Sahru YükselArmen Yuri Gasparyan
Jan 4, 2010·Macromolecular Rapid Communications·Paul Brochu, Qibing Pei
May 24, 2021·Journal of Inflammation·Bo RenYafan Song