Analysis of veterinary drug and pesticide residues in animal feed by high-resolution mass spectrometry: comparison between time-of-flight and Orbitrap

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
María Luz Gómez-PérezAntonia Garrido Frenich

Abstract

The use of medium-high-resolution mass spectrometers (M-HRMS) provides many advantages in multi-residue analysis. A comparison between two mass spectrometers, medium-resolution (MRMS) time-of-flight (TOF) and high-resolution (HRMS) Orbitrap, has been carried out for the analysis of toxic compounds in animal feed. More than 300 compounds belonging to several classes of veterinary drugs (VDs) and pesticides have been determined in different animal feed samples using a generic extraction method. The use of a clean-up procedure has been evaluated in both instruments, and several validation parameters have been established, such as the matrix effect, linearity, recovery and sensitivity. Finally, both instruments have been used during the analysis of 18 different feed samples (including chicken, hen, rabbit and horse). Some VDs (sulfadiazine, trimethoprim, robenidine and monensin sodium) and one pesticide (chlorpyrifos) have been identified. In general, better results were obtained using the Orbitrap, such as sensitivity (1-12.5 µg kg(-1)) and recovery values (60-125%). Moreover, this analyser had several software tools, which reduced the time for data processing and were easy to use, performing quick screening for more than 450 comp...Continue Reading

References

Apr 15, 2010·Avian Pathology : Journal of the W.V.P.A·A LanckrietF Van Immerseel
Apr 16, 2011·Journal of Agricultural and Food Chemistry·Sílvia BorràsJacinto Guiteras
Jun 29, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·H KadarB Le Bizec
Sep 11, 2012·Journal of Chromatography. a·Michal HolčapekMiroslav Lísa
Jan 25, 2013·Journal of Agricultural and Food Chemistry·Jaime Nácher-MestreFélix Hernández
Apr 30, 2013·Journal of Chromatography. a·Kaklamanos GeorgeChristoph von Holst

❮ Previous
Next ❯

Citations

Feb 6, 2018·Environmental Science and Pollution Research International·Yasser El-Nahhal, Raed Lubbad
May 20, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Shizuka Saito-ShidaHiroshi Akiyama
Oct 19, 2017·Journal of Food Protection·Rong-Wei HanJun Wang
Dec 19, 2017·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O V MaslovaE N Efremenko
Aug 25, 2018·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Louise JankTânia Mara Pizzolato
Jan 10, 2020·Journal of Food Protection·Wen-Qing ZhangRong-Wei Han
Feb 14, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Steven McGeehanPatricia Talcott
Jun 30, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Nho-Eul SongTae Gyu Nam
May 1, 2020·Analytical and Bioanalytical Chemistry·Sherri B Turnipseed, Hiranthi Jayasuriya
Oct 22, 2020·Toxicology Mechanisms and Methods·Lailah Cristina de Carvalho AbrãoIsarita Martins

❮ Previous
Next ❯

Software Mentioned

Orbitrap
ToxID
[UNK]
QuEChERS
MassLynx

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.