Analysis of Visual Field Defects Obtained with Semiautomated Kinetic Perimetry in Patients with Leber Hereditary Optic Neuropathy

Journal of Ophthalmology
Katarzyna NowomiejskaRobert Rejdak

Abstract

To analyse visual field (VF) defects obtained using semiautomated kinetic perimetry (SKP) in patients suffering from Leber hereditary optic neuropathy (LHON). Twenty-two eyes of eleven consecutive LHON male patients with confirmed mitochondrial 11778G>A DNA mutation were prospectively examined with the V4e stimulus of SKP in both eyes. The mean time after the onset of LHON was one year. The area of obtained isopters was measured in square degrees (deg2). Additionally, static automated perimetry (SAP) within 30° was performed. Visual acuity ranged from counting fingers to 50 cm to 0.4. VFs obtained with SKP showed central scotomas in 18 eyes (82%); the periphery of the VF in these eyes remained intact. The mean area of central scotoma was 408.8 deg2, and the mean area of the peripheral VF was 12291.1 deg2; SAP also revealed central scotoma in these patients. In four eyes (18%) with the worst visual acuity, only the residual central island of VF was found using SKP (mean area 898.4 deg2). SAP was difficult to obtain in these patients. SKP provides additional clinical information in regard to the visual function of LHON patients. SKP enables the quantification of the area of central scotoma, preserved peripheral VF, and residual c...Continue Reading

References

Oct 1, 1990·Brain : a Journal of Neurology·G T Plant, V H Perry
Apr 15, 1999·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·D S MojonM Hirano
Aug 14, 1999·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H ThiemeM H Foerster
Jan 9, 2003·American Journal of Human Genetics·P Yu-Wai-ManP F Chinnery
Feb 10, 2004·Progress in Retinal and Eye Research·Valerio CarelliAlfredo A Sadun
Jun 13, 2006·American Journal of Ophthalmology·Nancy J NewmanRoger E Turbin
Nov 24, 2006·Investigative Ophthalmology & Visual Science·Piero BarboniValerio Carelli
Nov 13, 2008·Journal of Medical Genetics·P Yu-Wai-ManP F Chinnery
Jun 16, 2009·Brain : a Journal of Neurology·Matthew Anthony KirkmanPatrick Francis Chinnery
Dec 19, 2009·Japanese Journal of Ophthalmology·Masato WakakuraYuko Emoto
Jul 20, 2010·Neurologic Clinics·Beau B Bruce, Nancy J Newman
Apr 25, 2012·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A F ScheuerleK Rohrschneider
Nov 22, 2013·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Elke K AltpeterSusanne Trauzettel-Klosinski
Jun 3, 2014·BMC Ophthalmology·Katarzyna NowomiejskaRobert Rejdak
Apr 18, 2015·BMC Ophthalmology·Ayako MizoguchiSusumu Ishida

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