Analysis of visual system development in Drosophila melanogaster: mutations at the Glued locus

Developmental Biology
P J Harte, D R Kankel

Abstract

We have analyzed several aspects of the development of flies carrying mutations at the Glued locus. Optic lobe abnormalities in individuals heterozygous for the original Glued allele were previously shown to result from an action of this mutation in the retinula cells. We have estimated when the functioning of this gene or its product is required for normal visual system development by using genetic mosaicism induced by somatic recombination and temperature shifts of a temperature-sensitive mutation at this locus. Both methods point to a period in the mid-third instar, suggesting that early events in the formation of ommatidia and/or late events in the program of retinal cells are affected. Application of a new histological stain for developing axons indicates that individuals heterozygous for Glued exhibit abnormalities in the retinula fiber projection by the late third instar. Thus, the adult phenotype is not solely the result of later cellular degeneration or rearrangement. Beneath M+ Gl+ clones which encompass the entire eye were found optic lobe abnormalities with features not seen in either other mosaics or Gl heterozygotes. The possibility that these abnormalities result from temporal asynchrony in the development of eye...Continue Reading

References

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Citations

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S L Helfand, J R Carlson
Oct 1, 1992·Current Opinion in Neurobiology·T A Schroer
May 30, 2006·Biochimica Et Biophysica Acta·Erica Chevalier-Larsen, Erika L F Holzbaur
Mar 1, 2006·Biochimica Et Biophysica Acta·Francois Gros-LouisGuy A Rouleau
Jul 21, 2001·Seminars in Cell & Developmental Biology·P H Taghert
Mar 11, 2003·Nature Genetics·Imke PulsKenneth H Fischbeck

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