PMID: 8959250Dec 10, 1996Paper

Analysis of west African hunters for foamy virus infections

AIDS Research and Human Retroviruses
P A GoepfertM J Mulligan

Abstract

Foamy viruses are a genus of complex retroviruses that infect a wide variety of mammals. However, a clear association with any disease process has yet to be proven for these viruses. A higher human seroprevalence was reported in African populations, perhaps due to exposure to simian foamy viruses (SFV) endemic in primates. However, the earlier serologic surveys were not confirmed by studies employing nucleic acid amplification. Foamy virus infections of humans clearly do occur as rare zoonoses among primate center or laboratory workers exposed to captive primates or their blood. We sought to detect foamy virus infections in a cohort of humans also presumed to be exposed to SFV, i.e., West African hunters. We constructed recombinant vaccinia viruses that expressed human foamy virus (HFV) Gag or Env polyproteins in mammalian cells. The sera from 17 monkey hunters or several controls were tested in radioimmunoprecipitation assays (RIPAs) against the recombinant HFV proteins. Chimpanzee sera or HFV-positive human sera immunoprecipitated gp130, the HFV Env precursor, as well as p74, the HFV Gag polyprotein. None of the hunters' sera recognized both of these recombinant proteins. We then employed a nested polymerase chain reaction (P...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S LagayeR Emanoil-Ravier
Sep 1, 1992·AIDS Research and Human Retroviruses·M C Debons-GuilleminJ Périés
Oct 1, 1991·Virology·A Mergia, P A Luciw
Apr 6, 1991·Lancet·H PerronJ M Seigneurin
May 1, 1990·The Journal of General Virology·K O NetzerV ter Meulen
Jun 1, 1990·AIDS Research and Human Retroviruses·M J MulliganR W Compans
Jan 1, 1987·Gene·A RethwilmR M Flügel
Jan 1, 1983·Medical Microbiology and Immunology·D Neumann-HaefelinH zur Hausen
Jan 10, 1980·Nature·A J Twigg, D Sherratt
Nov 1, 1995·Journal of Virology·P D BieniaszM O McClure
Nov 15, 1995·JAMA : the Journal of the American Medical Association·N Tamura, S Kira
Mar 10, 1995·Virology·M Schweizer, D Neumann-Haefelin
May 1, 1994·AIDS Research and Human Retroviruses·M SchweizerD Neumann-Haefelin
Oct 1, 1994·The Journal of General Virology·H HahnA Rethwilm
Feb 1, 1994·Journal of Neurology·J LyckeO Andersen
May 25, 1993·Biochimica Et Biophysica Acta·A Aguzzi
Jan 1, 1993·Intervirology·G WickB Grubeck-Loebenstein
Jan 1, 1993·Intervirology·D Neumann-HaefelinM Schweizer
Jan 1, 1996·Journal of Virology·D W Russell, A D Miller
Mar 21, 1996·Nature·R A Weiss

❮ Previous
Next ❯

Citations

Aug 1, 1997·Virus Research·A MergiaC Johnson
Apr 10, 1997·AIDS Research and Human Retroviruses·N FischerS Niewiesk
Jan 9, 2001·Clinical Microbiology Reviews·C D Meiering, M L Linial
Apr 28, 2010·PloS One·Boris MalyarchukIosif Tsybovsky
Feb 13, 2001·Molecular Phylogenetics and Evolution·P Gagneux, A Varki
Jan 2, 2003·Nature Reviews. Genetics·Maynard V Olson, Ajit Varki
Jan 1, 1997·Journal of Virology·P A GoepfertM J Mulligan
Jul 16, 1999·Journal of Clinical Microbiology·A S KhanM Shahabuddin
Aug 25, 2000·Genome Research·A Varki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.