Oct 31, 2007

Analysis of Yersinia pestis gene expression in the flea vector

Advances in Experimental Medicine and Biology
Viveka VadyvalooB Joseph Hinnebusch

Abstract

Yersinia pestis is the causative agent of plague. Unlike the other pathogenic Yersinia species, Y. pestis has evolved an arthropod-borne route of transmission, alternately infecting flea and mammalian hosts. Distinct subsets of genes are hypothesized to be differentially expressed during infection of the arthropod vector and mammalian host. Genes crucial for mammalian infection are referred to as virulence factors whilst genes playing a role in the flea vector are termed transmission factors. This article serves as a review of known factors involved in flea-borne transmission and introduces an 'in vivo' microarray approach to elucidating the genetic basis of Y. pestis infection of- and transmission by the flea.

  • References
  • Citations8

References

  • We're still populating references for this paper, please check back later.

Mentioned in this Paper

Biogenic Polyamines
Pathogenicity
Arthropod Vectors
Pathogenic Organism
Plague
Insect Vectors
Yersinia species
Gene Expression
Yersinia Infections
Plague Vaccine

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.