Analysis on the Expression and Prognostic Value of LncRNA FAF in Patients with Coronary Heart Disease.

BioMed Research International
Hai XuYicheng Jiang

Abstract

To investigate the expression and prognostic value of LncRNA FAF in patients with coronary heart disease. Patients and Methods. 97 patients with coronary heart disease who came to our hospital were selected as the research group (RG), and 97 healthy people who came to our hospital for physical examination during the same period were selected as the control group (CG). The serum LncRNA FAF, plasma homocysteine (HCY), lipoprotein A (Lp-a), serum tumor necrosis factor α (TNF-α), and high-sensitivity C-reactive protein (hsCRP) in the two groups of patients were detected, and their correlations were analyzed. Then, the predictive value and risk factors of FAF for poor prognosis of patients with coronary heart disease were analyzed. The expression of LncRNA FAF in the serum of patients in the RG was significantly lower than that in the CG, and the expressions of HCY, Lp-a, TNF-α, and hsCRP were significantly higher than those in the CG (p <0.05). The AUC of FAF in the diagnosis of coronary heart disease was more than 0.9. FAF was negatively correlated with the coronary lesion vessels, HCY, Lp-a, TNF-α, and hsCRP expressions in patients with coronary heart disease (p < 0.05). The ROC of FAF for predicting poor prognosis in patients wi...Continue Reading

References

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Mar 19, 2014·Journal of cardiology·Alireza EsteghamatiManouchehr Nakhjavani
Feb 14, 2015·Circulation Research·Shizuka Uchida, Stefanie Dimmeler
Oct 17, 2015·Journal of the American College of Cardiology·Runlin GaoUNKNOWN ABSORB China Investigators
Jul 22, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Aurélien JustetBruno Crestani
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Jun 22, 2019·Journal of Cellular Biochemistry·Yugeng LiHongli Lin
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Nov 12, 2019·Biochemical and Biophysical Research Communications·Jiateng SunLiansheng Wang
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Methods Mentioned

BETA
electrophoresis
PCR
ELISA

Software Mentioned

SPSS20
GraphPad Prism

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