Analysis on the level of IL-6, IL-21, AMH in patients with auto-immunity premature ovarian failure and study of correlation

Experimental and Therapeutic Medicine
Shulan SunRuiqin Yue

Abstract

Expression of interleukin-6 (IL-6), interleukin-21 (IL-21) and anti-müllerian hormone (AMH) in premature ovarian failure (POF) patients were observed to explore the correlation of each indicator and its significance in POF. One hundred and forty-two patients diagnosed with POF in Binzhou City Center Hospital from June 2014 to December 2015 were selected as the observation group. At the same time, another 140 healthy women were selected as the control group. The serum levels of IL-6, IL-2l, AMH, follicle stimulating hormone (FSH) and luteinizing hormone (LH), estradiol (E2), testosterone (T) and basal antral follicle count (AFC), and mean ovarian volume (MOV) were determined and compared; correlation analysis of IL-6, IL-2l and AMH with other indicators was performed. Compared to the control group, the serum levels of IL-6, IL-21, FSH and LH in the observation group were significantly higher (P<0.05), while E2, T, AMH levels in the serum, AFC and MOV were significantly lower (P<0.05). Spearman's correlation analysis showed that IL-6, IL-21 was positively correlated with FSH and LH (P<0.05), but negatively correlated with E2, T and MOV (P<0.05). AMH was negatively correlated with FSH and LH, but positively correlated with E2, T a...Continue Reading

References

Aug 1, 1981·Fertility and Sterility·C B CoulamR V Randall
Feb 1, 1996·Fertility and Sterility·G S ConwayH S Jacobs
Sep 14, 2001·American Journal of Reproductive Immunology : AJRI·V P ChernyshovZ B Khominskaya
Aug 23, 2006·Human Reproduction·A La MarcaA Volpe
Nov 1, 2006·Fertility and Sterility·Michael D WittenbergerLawrence M Nelson
Jan 20, 2007·Blood·Rong ZengWarren J Leonard
May 15, 2007·Hormone Research·Deepti Goswami, Gerard S Conway
Aug 28, 2007·Annals of the Rheumatic Diseases·A H SawalhaJ B Harley
Oct 24, 2007·Annual Review of Immunology·Rosanne Spolski, Warren J Leonard
Dec 11, 2008·The Journal of Clinical Endocrinology and Metabolism·Erik A H KnauffUNKNOWN Dutch Premature Ovarian Failure Consortium
Jan 14, 2009·The Journal of Experimental Medicine·Oliver DienzMercedes Rincon
Mar 25, 2009·Journal of Autoimmunity·Pierre Youinou, Christophe Jamin
Jul 14, 2009·Current Opinion in Rheumatology·Fabrizio De Benedetti
Oct 27, 2009·Rheumatology·Jean-Michel Dayer, Ernest Choy
Jan 19, 2010·Human Immunology·Xiaoyin NiuGuangjie Chen
May 11, 2012·International Journal of General Medicine·Alieh GhassemzadehElaheh Beyhaghi
Dec 24, 2013·Molecular Cytogenetics·Artur BekeVeronika Karcagi

❮ Previous
Next ❯

Citations

Feb 19, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Osman EvliyaogluJosef van Helden
Feb 12, 2021·Frontiers in Pharmacology·Liuqing YangQin Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
biopsy

Software Mentioned

SPSS18
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.