Analytic Validation of the Automated Bone Scan Index as an Imaging Biomarker to Standardize Quantitative Changes in Bone Scans of Patients with Metastatic Prostate Cancer

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Aseem AnandAnders Bjartell

Abstract

A reproducible and quantitative imaging biomarker is needed to standardize the evaluation of changes in bone scans of prostate cancer patients with skeletal metastasis. We performed a series of analytic validation studies to evaluate the performance of the automated bone scan index (BSI) as an imaging biomarker in patients with metastatic prostate cancer. Three separate analytic studies were performed to evaluate the accuracy, precision, and reproducibility of the automated BSI. Simulation study: bone scan simulations with predefined tumor burdens were created to assess accuracy and precision. Fifty bone scans were simulated with a tumor burden ranging from low to high disease confluence (0.10-13.0 BSI). A second group of 50 scans was divided into 5 subgroups, each containing 10 simulated bone scans, corresponding to BSI values of 0.5, 1.0, 3.0, 5.0, and 10.0. Repeat bone scan study: to assess the reproducibility in a routine clinical setting, 2 repeat bone scans were obtained from metastatic prostate cancer patients after a single 600-MBq (99m)Tc-methylene diphosphonate injection. Follow-up bone scan study: 2 follow-up bone scans of metastatic prostate cancer patients were analyzed to determine the interobserver variability be...Continue Reading

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Citations

Oct 14, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Arthur LetellierNicolas Aide
Oct 7, 2017·Radiological Physics and Technology·Shota HosokawaMasahiro Fukushi
Apr 11, 2018·Clinical Physiology and Functional Imaging·Reza KabotehElin Trägårdh
May 1, 2019·Prostate Cancer and Prostatic Diseases·Jose Mauricio MotaMichael J Morris
May 31, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Kenichi NakajimaAtsushi Mizokami
May 3, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Tomohiko YamaneIchiro Matsunari
Jan 6, 2021·Annals of Nuclear Medicine·Tomohiko YamaneIchiei Kuji
Oct 10, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Steven M Larson
Jul 22, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·David MinarikElin Trägårdh
Oct 6, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Aseem AnandAnders Bjartell
Apr 8, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Aseem U Anand, David Minarik
May 27, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marie BiethMarkus Schwaiger
Jul 23, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Aseem AnandDavid Minarik
Sep 3, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marie Øbro FosbølJann Mortensen

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