Analytical and ecotoxicological studies on degradation of fluoxetine and fluvoxamine by potassium ferrate

Environmental Technology
Przemysław DrzewiczGrzegorz Nałęcz-Jawecki

Abstract

A large amount of pharmaceuticals are flushed to environment via sewage system. The compounds are persistent in environment and are very difficult to remove in drinking water treatment processes. Degradation of fluoxetine (FLU) and fluvoxamine (FLX) by ferrate(VI) were investigated. For the 10 mg/L of FLU and FLX, 35% and 50% of the compounds were degraded in the presence of 50 mg/L FeO42- within 10 minutes, respectively. After 10 minutes of the reaction, degradation of FLU and FLX is affected by formation of by-products which were likely more reactive with ferrate and competed in the reaction with FeO42-. In the case of FLU, the identified degradation by-products were hydrofluoxetine, N-methyl-3-phenyl-2-propen-1-amine, 4-(trifluoromethyl)phenol and 1-{[(1R,S)-1-Phenyl-2-propen-1-yl]oxy}-4-(trifluoromethyl)benzene. In the case of FLX, the degradation by-products were fluvoxamine acid and 5-methoxy-1-[4-(trifluoromethyl)phenyl]pent-2-en-1-imine. The results of the ecotoxicological study based on protozoa Spirostomum ambiguum have shown that 50 mg/L FeO42- reduced toxicity of 10 mg/L of FLU and FLX by around 50%. However, in the case of FLX, the results of the ecotoxicological study suggested formation of slightly more toxic com...Continue Reading

References

Jul 1, 1983·European Journal of Drug Metabolism and Pharmacokinetics·H OvermarsL C Post
Sep 24, 2004·Environmental Toxicology and Chemistry·Theodore B HenryMarsha C Black
Feb 15, 2005·Environmental Science & Technology·Monica W LamScott A Mabury
Mar 31, 2005·Journal of Pharmaceutical and Biomedical Analysis·Jeong-Wook Kwon, Kevin L Armbrust
Oct 7, 2006·Environmental Toxicology and Chemistry·Jeong-Wook Kwon, Kevin L Armbrust
Dec 4, 2009·Journal of Hazardous Materials·Lúcia H M L M SantosM C B S M Montenegro
Sep 18, 2010·Integrated Environmental Assessment and Management·Ken D OakesMark R Servos
Oct 27, 2010·The Journal of Physical Chemistry. a·Przemysław DrzewiczJonathan W Martin
Feb 8, 2014·Aquatic Toxicology·Bryan W Brooks
Oct 17, 2014·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Brian J YatesVirender K Sharma
Feb 11, 2015·Accounts of Chemical Research·Virender K SharmaRajender S Varma
Jan 12, 2016·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Lei ZhouTiebo Xiao
Mar 11, 2016·Environmental Science and Pollution Research International·Vanessa Honda Ogihara SilvaSueli Ivone Borrely

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Citations

Sep 8, 2021·Environmental Science and Pollution Research International·Maciej ThomasBalamurugan Panneerselvam

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Methods Mentioned

BETA
deamination

Software Mentioned

QTRAP

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