Analytical and functional determination of polymyxin B protein binding in serum

Antimicrobial Agents and Chemotherapy
Henrietta AbodakpiVincent H Tam

Abstract

To enhance our understanding of the pharmacological properties of polymyxin B, serum protein binding for polymyxin B1, B2, and B3 and for isoleucine-polymyxin B1 was evaluated. Using equilibrium dialysis and ultrafiltration, comparable protein binding was found in all 4 components of polymyxin B (92% to 99%). Protein binding in human serum was further assessed using a functional assay, the results of which were in general agreement with previous findings (approximately 90%).

References

Oct 6, 2007·Diagnostic Microbiology and Infectious Disease·Andrea L H KwaVincent H Tam
Oct 24, 2009·Journal of Pharmaceutical Sciences·Stephan SchmidtHartmut Derendorf
May 24, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ana M SandriAlexandre P Zavascki

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Citations

Jan 13, 2017·Journal of Natural Products·Sivashangarie SivanesanTony Velkov
Nov 2, 2016·Antimicrobial Agents and Chemotherapy·Visanu ThamlikitkulVincent H Tam
Aug 4, 2021·European Journal of Clinical Pharmacology·Ya-Qian LiQi Pei
Aug 5, 2021·Pediatric Pulmonology·Jonathan J GrantDavid C Young

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