Analytical approaches for myocardial fibrillation signals.

Computers in Biology and Medicine
Balvinder S HandaFu Siong Ng

Abstract

Atrial and ventricular fibrillation are complex arrhythmias, and their underlying mechanisms remain widely debated and incompletely understood. This is partly because the electrical signals recorded during myocardial fibrillation are themselves complex and difficult to interpret with simple analytical tools. There are currently a number of analytical approaches to handle fibrillation data. Some of these techniques focus on mapping putative drivers of myocardial fibrillation, such as dominant frequency, organizational index, Shannon entropy and phase mapping. Other techniques focus on mapping the underlying myocardial substrate sustaining fibrillation, such as voltage mapping and complex fractionated electrogram mapping. In this review, we discuss these techniques, their application and their limitations, with reference to our experimental and clinical data. We also describe novel tools including a new algorithm to map microreentrant circuits sustaining fibrillation.

Citations

Nov 15, 2019·Scientific Reports·Xinyang LiFu Siong Ng
Feb 18, 2020·Circulation. Arrhythmia and Electrophysiology·Balvinder S HandaFu Siong Ng
Jul 21, 2020·Arrhythmia & Electrophysiology Review·Caroline H RoneyNicholas S Peters

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Methods Mentioned

BETA
fluorescence microscopy

Software Mentioned

EnsiteTM Velocity
CARTO
NavX

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