Analytical considerations for trace determinations of drugs in breast milk

Journal of Pharmaceutical and Biomedical Analysis
D T Rossi, D S Wright

Abstract

Recent scientific and regulatory interest in lacteal excretion of drugs has prompted this review of bioanalytical sample preparation techniques for milk. The composition and properties of milk are reviewed, with emphasis on how the sample preparation is affected. The most important principals of mammary gland pharmacology, including protein binding, ion trapping and liquid solubility, are described. Because adequate milk volume is difficult to obtain from some smaller rodent species, special arrangements for sample collection, control preparation and assay standardization often need to be made. Several commonly-used sample preparation approaches for drugs in milk, including direct injection, dialysis and ultrafiltration, protein precipitation, liquid-liquid extraction, solid-phase extraction and immunoaffinity extraction. Have been reported with varying degrees of success. The advantages and disadvantages of each of these approaches is discussed.

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Citations

Apr 29, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Antonia M CalafatLarry L Needham
Aug 6, 2003·Journal of Pharmaceutical and Biomedical Analysis·Vojko Kmetec, Robert Roskar
Mar 7, 2000·Journal of Pharmaceutical and Biomedical Analysis·K L HoffmanD T Rossi
Apr 2, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Robert Roskar, Vojko Kmetec
Jul 3, 2004·The British Journal of Nutrition·José G Dorea
Apr 21, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Kirsten Salado-RasmussenTerese Lea Katzenstein
Aug 8, 2008·Environment International·Giuseppe LatiniJurgen Angerer
Aug 14, 2013·Biomedical Chromatography : BMC·Kanumuri Siva Rama Raju Wahajuddin
Jun 21, 2015·Analytica Chimica Acta·Eduardo Carasek, Josias Merib
Jul 17, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Fotios BaxevanisNikoletta Fotaki
Nov 27, 2002·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Evan J BeggKenneth F Ilett
Jan 22, 2019·Bioanalysis·Gabriela de Oliveira SilveiraMauricio Yonamine
Jul 16, 2013·Therapeutic Drug Monitoring·María E MarsonGuido Mastrantonio
Sep 8, 2020·Bioanalysis·Wilson José Ramos Santos, Bruno Spinosa De Martinis
Mar 16, 2017·Journal of Clinical Pharmacy and Therapeutics·A Van EeckhautY Michotte

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