Analytical construct resins for analysis of solid-phase chemistry

Chemistry : a European Journal
Miles S CongreveJan J Scicinski

Abstract

Rapid and unambiguous analysis of reactions performed on resin supports can be achieved by using "analytical constructs". These resins allow the synthesis of materials using solid-phase methods in the usual manner, but they also contain functionality enabling cleavage of analytically enhanced derivatives of the resin-bound products. This is possible due to the use of two linkers bound in series to the polymer. Cleavage at the first linker yields the products attached to an analytical enhancer that facilitates detection. Orthogonal cleavage at the second linker yields the desired products in the usual manner.

Citations

Dec 17, 2014·Journal of Proteomics·Maciej ModzelPiotr Stefanowicz
Apr 4, 2017·Chemistry : a European Journal·Irina ProtasovaStefan Bräse
Feb 8, 2007·Organic & Biomolecular Chemistry·Christophe Portal, Mark Bradley
May 5, 2007·Angewandte Chemie·Franziska Mende, Oliver Seitz
Jul 12, 2005·Journal of Combinatorial Chemistry·Viktor Krchnák, Jaroslav Zajícek
Aug 4, 2004·The Journal of Organic Chemistry·A Jonathan WillsShankar Balasubramanian

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