Analytical Interference by Contrast Agents in Biochemical Assays

Contrast Media & Molecular Imaging
Sigrid OtnesHenrik S Thomsen

Abstract

To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently performed biochemical assays. One-day-old plasma, serum, and whole blood were spiked with doses of each agent such that the gadolinium agents and the iodine agents reached concentrations of 0.5 mM and 12 mg iodine/mL, respectively. Subsequently, 12 assays were reexamined using 1/2 and 1/4 of these CA concentrations. The results were assessed statistically by a paired Student's t-test. Iodixanol produced a negative interference on the bicarbonate (p = 0.011), lactate dehydrogenase (p < 0.0001), and zinc (p = 0.0034) assays and a positive interference on the albumin (p = 0.0062), calcium (p < 0.0001), ionized calcium (p = 0.0086), iron (p < 0.0001), and potassium (p = 0.0003) assays. Iomeprol produced a negative interference on the bicarbonate (p = 0.0057) and magnesium (p = 0.0001) assays and a positive interference on the calcium (p < 0.0001) and potassium (p = 0.0012) assays. Gadoxetate disodium produced a negative interference on the iron (p < 0.0001)...Continue Reading

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Citations

Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Iwona Jarocka-KarpowiczZenon Dionizy Mariak
Dec 14, 2019·Advances in Chronic Kidney Disease·Edward R SmithStephen G Holt

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Methods Mentioned

BETA
flow cytometry
protein assay

Software Mentioned

R

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