Analytical methodologies for the determination of benzodiazepines in biological samples

Journal of Pharmaceutical and Biomedical Analysis
Karolina PersonaWojciech Piekoszewski

Abstract

Benzodiazepine drugs belong to important and most widely used medicaments. They demonstrate such therapeutic properties as anxiolytic, sedative, somnifacient, anticonvulsant, diastolic and muscle relaxant effects. However, despite the fact that benzodiazepines possess high therapeutic index and are considered to be relatively safe, their use can be dangerous when: (1) co-administered with alcohol, (2) co-administered with other medicaments like sedatives, antidepressants, neuroleptics or morphine like substances, (3) driving under their influence, (4) using benzodiazepines non-therapeutically as drugs of abuse or in drug-facilitated crimes. For these reasons benzodiazepines are still studied and determined in a variety of biological materials. In this article, sample preparation techniques which have been applied in analysis of benzodiazepine drugs in biological samples have been reviewed and presented. The next part of the article is focused on a review of analytical methods which have been employed for pharmacological, toxicological or forensic study of this group of drugs in the biological matrices. The review was preceded by a description of the physicochemical properties of the selected benzodiazepines and two, very often ...Continue Reading

References

Jul 2, 1997·JAMA : the Journal of the American Medical Association·B HemmelgarnG Pinard
Aug 13, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·O H Drummer
Jul 2, 2004·Therapeutic Drug Monitoring·Jean-Pierre Goullé, Jean-Pierre Anger
Nov 2, 2004·Journal of Analytical Toxicology·Lutea A A de JongKees Ensing
Jun 10, 2005·Forensic Science International : Synergy·F M WylieJ S Oliver
Jun 10, 2005·Forensic Science International : Synergy·Pascal KintzVincent Cirimele
Aug 23, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Simon N MuchohiCharles R J C Newton
Sep 13, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·O QuintelaM López-Rivadulla
Oct 13, 2005·International Journal of Legal Medicine·Franz E DussyThomas A Briellmann
Oct 18, 2005·Forensic Science International : Synergy·Brice M R AppenzellerRobert Wennig
Dec 28, 2005·Journal of Pharmaceutical and Biomedical Analysis·Xiao-Pen LeeKeizo Sato
Feb 18, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Aurélie BugeyChristian Staub
Mar 7, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sung-Hoon AhnSuk-Jae Chung
Mar 7, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·O QuintelaM López-Rivadulla
Apr 20, 2006·Forensic Science International : Synergy·Stuart DicksonScott Hampton
May 19, 2006·Forensic Science International : Synergy·Rachel C Irving, Stuart J Dickson
Jul 1, 2006·Forensic Science International : Synergy·Jeffery Hackett, Albert A Elian
Mar 31, 2007·Journal of Pharmaceutical and Biomedical Analysis·Mitona PujadasRafael de la Torre
Apr 28, 2007·Journal of Separation Science·Victoria F SamanidouIoannis N Papadoyannis
Dec 21, 2007·Journal of Analytical Toxicology·Christine MooreMichael Zumwalt
Jun 12, 2008·Journal of Analytical Toxicology·S HegstadA S Christophersen
Aug 12, 2008·Journal of Separation Science·Laura MercoliniMaria Augusta Raggi
Sep 6, 2008·Journal of Pharmaceutical and Biomedical Analysis·Erasmus Cudjoe, Janusz Pawliszyn
Nov 13, 2008·Journal of Separation Science·Mohammad Nasir UddinIoannis N Papadoyannis
Feb 20, 2009·Journal of Separation Science·Nikolaos RaikosHeleni Tsoukali

❮ Previous
Next ❯

Citations

May 5, 2017·Drug Testing and Analysis·Kieran R ManchesterPeter D Maskell
Jun 9, 2020·Journal of Analytical Toxicology·Maarten DegreefAlexander L N van Nuijs
Jun 14, 2019·The Analyst·Lailah Cristina de Carvalho Abrão, Eduardo Costa Figueiredo
Oct 5, 2019·Journal of Analytical Methods in Chemistry·Zidane QriouetHassan Sefrioui
Dec 15, 2018·Luminescence : the Journal of Biological and Chemical Luminescence·Wan Qiu XiaJian Ping Wang
Mar 5, 2021·Biomedical Chromatography : BMC·Seyed Mosayeb DaryanavardMohamed Abdel-Rehim
Feb 27, 2017··Maciej S. WróbelJanusz Smulko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Recent Developments in Alcoholism : an Official Publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism
L E Hollister
© 2021 Meta ULC. All rights reserved