Analytical model of the feto-placental vascular system: consideration of placental oxygen transport

Royal Society Open Science
Parisa Mirbod

Abstract

The placenta is a transient vascular organ that enables nutrients and blood gases to be exchanged between fetal and maternal circulations. Herein, the structure and oxygen diffusion across the trophoblast membrane between the fetal and maternal red blood cells in the feto-placental vasculature system in both human and mouse placentas are presented together as a functional unit. Previous models have claimed that the most efficient fetal blood flow relies upon structures containing a number of 'conductive' symmetrical branches, offering a path of minimal resistance that maximizes blood flow to the terminal villi, where oxygen diffusion occurs. However, most of these models have disregarded the actual descriptions of the exchange at the level of the intermediate and terminal villi. We are proposing a 'mixed model' whereby both 'conductive' and 'terminal' villi are presumed to be present at the end of single (in human) or multiple (in mouse) pregnancies. We predict an optimal number of 18 and 22 bifurcation levels in the human and the mouse placentas, respectively. Wherever possible, we have compared our model's predictions with experimental results reported in the literature and found close agreement between them.

References

Jan 1, 1990·Anatomy and Embryology·M CastellucciP Kaufmann
Jun 1, 1988·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·E P Shronts
Nov 1, 1987·American Journal of Obstetrics and Gynecology·R B HowardM H Maguire
Jun 1, 1967·Journal of Applied Physiology·G MeschiaP D Bruns
Apr 16, 1998·American Journal of Obstetrics and Gynecology·B RichardsonR Natale
Dec 10, 1999·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C LeesK H Nicolaides
Sep 25, 2001·American Journal of Obstetrics and Gynecology·F LackmanB Richardson
Jul 1, 1965·Anesthesiology·C B MARTIN
Feb 20, 2004·Biology of Reproduction·Philip M CoanGraham J Burton
Jun 12, 2004·Medical Physics·A H ReisM Aydin
Jul 9, 2004·Emergency Medicine Australasia : EMA·Anthony F T Brown
Apr 28, 2005·The Annals of Pharmacotherapy·Mai-Trang N DangSteven R Kayser
Mar 1, 1926·Proceedings of the National Academy of Sciences of the United States of America·C D Murray
Apr 11, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Junwu Mu, S Lee Adamson
Jan 2, 2007·Placenta·A M Carter
Nov 2, 2007·Journal of Anatomy·Z GordonO Eytan
Jan 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·J YangR M Henkelman
Oct 1, 2011·Journal of Theoretical Biology·J S GillD D Vvedensky
Oct 5, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Igor L ChernyavskyOliver E Jensen
Jan 24, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Monique Y RennieJohn G Sled
Jun 27, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Monique Y RennieS Lee Adamson
Sep 28, 2014·Journal of Theoretical Biology·A S SerovM Filoche
Apr 7, 2015·Interface Focus·A R ClarkJ L James
Sep 15, 2015·Geburtshilfe und Frauenheilkunde·S Bosselmann, G Mielke
Oct 24, 2015·Journal of Applied Physiology·A S SerovMarcel Filoche
Mar 10, 2016·Lancet·Jennifer J AdibiRichard H Beigi
Apr 6, 2016·Biochimica Et Biophysica Acta·N PanitchobB G Sengers
Jun 22, 2016·Placenta·Romina Plitman MayoMichelle L Oyen

❮ Previous
Next ❯

Citations

Nov 8, 2018·Journal of Molecular Endocrinology·Bethany HartEmilyn U Alejandro
Jul 3, 2019·Reproductive Biology and Endocrinology : RB&E·Liang ZhaoLifang Sun
Aug 4, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Alys R ClarkJoanna L James
Sep 11, 2019·Physical Review. E·Changwoo Kang, Parisa Mirbod
Nov 12, 2020·Annals of Biomedical Engineering·Chi Wei OngChoon Hwai Yap
Jan 10, 2021·Annals of Biomedical Engineering·Mackenzie L Wheeler, Michelle L Oyen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nederlands tijdschrift voor geneeskunde
B S TEN BERGE
Trabajos del Instituto Cajal de investigaciones biológicas
F González GómezF Bullón Sopelana
© 2022 Meta ULC. All rights reserved