PMID: 20631441Jul 16, 2010Paper

Analytical parameters for amplitude-modulated multiplexed flow analysis

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
Yohei KurokawaHideji Tanaka

Abstract

Analytical conditions of amplitude-modulated multiplexed flow analysis, the basic concept of which was recently proposed by our group, are investigated for higher sample throughput rate. The performance of the improved system is evaluated by applying it to the determination of chloride ions. The flow rates of two sample solutions are independently varied in accordance with sinusoidal voltage signals, each having different frequency. The solutions are merged with a reagent solution and/or a diluent, while the total flow rate is held constant. Downstream, the analytical signal V(d) is monitored with a spectrophotometer. The V(d) shows a complicated profile resulting from amplitude modulated and multiplexed information on the two samples. The V(d) can, however, be deconvoluted to the contribution of each sample through fast Fourier transform (FFT). The amplitudes of the separated wave components are closely related to the concentrations of the analytes in the samples. By moving the window for FFT analysis with time, a temporal profile of the amplitudes can be obtained in real-time. Analytical conditions such as modulation period and system configuration have been optimized using aqueous solutions of Malachite Green (MG). Adequate ...Continue Reading

References

Sep 1, 1957·American Journal of Clinical Pathology·L T SKEGGS
Jun 30, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hideji Tanaka, Tsutomu Baba
Jul 16, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Takeshi UemuraHideji Tanaka

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Citations

Mar 19, 2011·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Koji InuiHideji Tanaka
Jun 13, 2012·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Haruka YoshidaHideji Tanaka
Dec 12, 2017·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Takuya SumitomoHideji Tanaka

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